5-Chloro-2-hydroxynicotinic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 38076-80-1 |
| Product name | 5-Chloro-2-hydroxynicotinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Chloro-2-hydroxynicotinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Chloro-2-hydroxynicotinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Chloro-2-hydroxynicotinic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used in the synthesis of antithrombotic agents, such as thrombin inhibitors | Employed as a key intermediate in chemical synthesis |
| Pharmaceuticals | Used in the synthesis of nicotinic acid receptor agonists | Employed as a key intermediate in chemical synthesis |
| Chemicals | Used in the synthesis of other complex nicotinic acid derivatives | Applied in backbone construction via esterification, acylation, and related reactions |
Manufacturing Quality Control of 5-Chloro-2-hydroxynicotinic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, acetone, ethyl acetate) against calibration standards. |
| Moisture Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to determine water content via stoichiometric reaction. |
| Heavy Metals | ICP-OES | Multi-element detection after acid digestion, measuring total heavy metals (Pb, Cd, Hg, As, Cr) by atomic emission spectroscopy. |
| Chloride Ion Impurity | Ion Chromatography | Separation and quantification of chloride anions using suppressed conductivity detection with a carbonate eluent. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing (700-800 C) to assess inorganic ash content. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP/Ph. Eur. guidelines. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample to determine D10, D50, D90 values based on light scattering principles. |
| Organic Volatile Impurities (OVI) | GC-MS | Targeted and non-targeted screening of volatile organic impurities using mass spectral library matching and retention indexing. |
| Sulfated Ash | Gravimetric Analysis | Weighing residue after ignition with sulfuric acid treatment to assess sulfate-forming inorganic impurities. |
Technical Specifications of 5-Chloro-2-hydroxynicotinic acid
| Test Item | Specification |
|---|---|
| Appearance | Green solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 182–186°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Chloro-2-hydroxynicotinic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Chloro-2-hydroxynicotinic acid
Safety Information of 5-Chloro-2-hydroxynicotinic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Chloro-2-hydroxynicotinic acid
Industrial 5-Chloro-2-hydroxynicotinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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