tert-butyl 4-((piperazin-1-yl)methyl)piperidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 381722-48-1 |
| Product name | tert-butyl 4-((piperazin-1-yl)methyl)piperidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 381722-48-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 381722-48-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 381722-48-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing G protein-coupled receptor (GPCR)-targeting drug candidates, such as 5-HT6 receptor antagonists | Multi-step organic synthesis: Boc-protected piperazine is condensed with 1-Boc-4-formylpiperidine, followed by reductive amination and purification via crystallization |
| Pharmaceutical R&D | Key building block for constructing piperazine-piperidine bicyclic pharmacophores, as found in Alzheimer’s disease therapeutic candidates (e.g., analogues of PF-07282392) | Serves as a nitrogen-containing side-chain precursor in palladium-catalyzed cross-coupling or nucleophilic substitution reactions; active amino group is unmasked by subsequent Boc deprotection |
Manufacturing Quality Control of 381722-48-1
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area to a reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time relative to reference standards or threshold limits. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, THF, DMF) against calibrated standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generation to determine water content based on stoichiometric reaction with Karl Fischer reagent. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification by inductively coupled plasma mass spectrometry after acid digestion and dilution. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after high-temperature incineration at 700-800 C and weighing. |
| Optical Rotation | Polarimetry | Determination of specific rotation using sodium D-line light to assess chiral purity and enantiomeric identity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement via controlled heating of sample in capillary tube, observing solid-to-liquid phase change. |
| pH of Aqueous Solution | pH Meter | Electrochemical measurement of hydrogen ion activity in a saturated aqueous suspension or defined solution. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size by measuring angular variation in intensity of laser light scattered by dispersed particles. |
| Microbial Limits | Membrane Filtration | Quantitative recovery and enumeration of aerobic microorganisms using filtration, membrane transfer, and incubation on nutrient agar. |
Technical Specifications of 381722-48-1
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 120-125°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
| Odor | Characteristic, mild |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 381722-48-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 381722-48-1
Packaging of 381722-48-1
Industrial 381722-48-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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