2-Cyano-3-chloropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 38180-46-0 |
| Product name | 2-Cyano-3-chloropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Cyano-3-chloropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Cyano-3-chloropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Cyano-3-chloropyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing neonicotinoid insecticides such as imidacloprid and acetamiprid | Subjected to nucleophilic substitution with N-methyl-N'-nitroguanidine or analogous amine compounds, using 3-chloro-2-cyanopyridine as the starting material |
| Pharmaceuticals | Intermediate for synthesizing antiviral and antitumor agents | Coupled with nitrogen-containing heterocycles or amines to construct pyridine-containing bioactive molecular scaffolds |
| Dyes & Pigments | Intermediate for synthesizing nitrogen-containing heterocyclic dyes | Serves as a reactive site for the cyano and chloro functional groups, participating in condensation or substitution reactions to form colored compounds |
| Organic Synthesis | General fine chemical intermediate containing a pyridine ring | Undergoes nucleophilic substitution via the highly reactive chlorine atom, or the cyano group is converted into carboxylic acid, amide, and other functional groups |
Manufacturing Quality Control of 2-Cyano-3-chloropyridine
| Test Item | Common Testing Method | Method Description |
|---|---|---|
| Purity Determination | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 column with methanol/water or acetonitrile/buffer as mobile phase, and a UV detector (e.g., 254 nm) to quantify the main component purity and assess total impurity content. |
| Related Substances (Impurities) | HPLC or UPLC | Based on purity analysis, potential process impurities and degradation products are separated using gradient elution. The area normalization method or external standard method is used to quantify the content of each impurity. |
| Water Content | Karl Fischer Titration | Determine trace water in the sample by potentiometric or volumetric titration to ensure compliance with drying loss or water limit requirements (usually ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with a capillary column (e.g., DB-624), FID detector, and determine residual organic solvents (e.g., toluene, DMF) according to ICH Q3C guidelines. |
| Melting Point | Capsule Melting Point Determination | Use a digital melting point apparatus to measure the temperature range from initial melting to complete melting, serving as a physical constant to verify compound consistency (literature value approximately 95–98°C). |
| Appearance and Properties | Visual Inspection + Microscopic Observation | Observe whether it is a white to off-white crystalline powder without visible foreign matter; confirm crystal morphology under a microscope if necessary. |
| Loss on Drying | Oven Drying Weight Loss Method | Dry the sample at specified temperature (e.g., 105°C) and time, then calculate the percentage of weight loss to control volatile substances and adsorbed water. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine the total content of heavy metal elements such as lead, arsenic, cadmium, and mercury after sample digestion, ensuring compliance with pharmacopoeia or ICH Q3D limits (typically ≤20 ppm). |
| Content Determination | HPLC External Standard Method | Establish a standard curve using a known concentration reference standard, and calculate the absolute content of 3-chloro-2-cyano pyridine in the sample based on peak area (usually required ≥98.0%). |
| Structure Confirmation | Infrared Spectroscopy (IR), Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) | Compare characteristic functional groups (e.g., cyano, aromatic ring) via IR; confirm hydrogen and carbon environments via ¹H/¹³C NMR; identify molecular ion peaks (m/z = 138.5 [M+H]⁺) via MS to comprehensively confirm the structure. |
Technical Specifications of 2-Cyano-3-chloropyridine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 48–52°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Cyano-3-chloropyridine
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Cyano-3-chloropyridine
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Industrial 2-Cyano-3-chloropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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