China Factory Direct
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| CAS number | 38537-24-5 |
| Product name | Carbazole-d8 |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Organic Synthesis | Intermediate for synthesizing other organic compounds | Prepared via catalytic hydrogenation or oxidation |
| Pharmaceutical Industry | Intermediate in the synthesis of certain pharmaceuticals | Produced through multi-step organic synthesis |
| Polymer Materials | Production of high-performance polymer materials | Used as a monomer or comonomer in polymerization reactions |
| Dye Industry | Intermediate in the synthesis of certain dyes | Processed via organic reactions such as condensation and coupling |
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (¹H NMR, ¹³C NMR, ²H NMR) | Confirm the carbazole backbone structure and deuteration sites using proton, carbon, and deuterium spectra; verify the degree of substitution by observing the disappearance of hydrogen signals and characteristic deuterium signals at deuterated positions (typically C9). |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with a UV detector (e.g., 254 nm), and gradient elution with acetonitrile/water or methanol/water as mobile phases. Quantify purity by measuring the main peak area, with typical requirement of ≥98% for carbazole-D8. |
| Deuterium Incorporation Rate (D-Labeling Efficiency) | Mass Spectrometry (High-Resolution Mass Spectrometry, HRMS) | Obtain the molecular ion peak [M+H]⁺ using ESI or EI ionization. Compare the measured m/z value with the theoretical value (C₁₂H₇D₈⁺ = 177.138) to confirm the number of deuterium atoms and calculate the deuteration efficiency (e.g., ≥98%). |
| Residual Solvent Testing | Gas Chromatography (GC-FID/MS) | According to ICH Q3C guidelines, use headspace or direct injection to detect residual organic solvents such as ethanol, acetone, and dichloromethane, ensuring compliance with pharmaceutical-grade limits. |
| Moisture Content | Karl Fischer Titration | Determine trace moisture content using coulometric or volumetric methods. Ensure moisture content ≤0.5% (pharmaceutical grade standard) to avoid impacts on stability and reactivity. |
| Melting Point Determination | Melting Point Apparatus | Measure the melting point range of carbazole-D8 using a digital melting point apparatus (literature value approximately 110–113°C), used for identification and batch consistency evaluation. |
| Impurity Profile Analysis | HPLC-MS Coupling Technique | Combine HPLC separation with MS identification to detect and quantify potential impurities such as non-deuterated carbazole (C₁₂H₉N), oxidation products, or by-products, ensuring total impurity levels ≤2%. |
| UV Absorption Characteristics | UV-Visible Spectrophotometry (UV-Vis) | Measure absorption spectrum in the 200–400 nm range using ethanol or methanol as solvent. Characteristic absorption peaks appear around 270–290 nm, used for qualitative identification and concentration calculation (requires calibration curve). |
| Isotopic Abundance Distribution | Isotope Ratio Mass Spectrometry (IRMS) or High-Resolution MS | For high-precision applications, analyze the distribution of deuterium isotopes within the molecule (e.g., ratios of mono-deuterated, multi-deuterated species) to ensure controlled synthesis pathways. |
| Test Item | Specification |
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| Appearance | Off-white to brown solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 245-249°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.