4-Chloro-4'-fluorobutyrophenone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 3874-54-2 |
| Product name | 4-Chloro-4'-fluorobutyrophenone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-4'-fluorobutyrophenone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-4'-fluorobutyrophenone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-4'-fluorobutyrophenone
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of antidepressants (e.g., fluoxetine) | Used to construct the 4-chloro-4'-fluorobutyrophenone scaffold; active functional groups are introduced via reductive amination or condensation reactions |
| Pesticides | Intermediate in the preparation of insecticides or fungicides | Molecular structure is modified via halogenation, acylation, and related reactions to enhance biological activity |
| Fine Chemicals | Functionalized building block for organic synthesis | Applied in cross-coupling reactions (e.g., Suzuki coupling) or as a precursor to Grignard reagents |
Manufacturing Quality Control of 4-Chloro-4'-fluorobutyrophenone
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity Assay | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column and a UV detector (e.g., 254 nm). Quantifies the main component purity by external standard method or area normalization. The mobile phase is typically methanol/water or acetonitrile/water system. |
| Related Substances (Impurities) | HPLC (Gradient Elution) | Employs a gradient elution program to separate the main peak from potential impurity peaks. The relative content of each impurity is calculated based on peak areas, ensuring compliance with pharmacopoeial or internal quality standards. |
| Water Content | Karl Fischer Titration | Determines water content by quantitative reaction between Karl Fischer reagent and water in the sample, using potentiometric or volumetric titration. Suitable for trace moisture analysis. |
| Residual Solvents | Gas Chromatography (GC-FID or GC-MS) | Headspace or direct injection is used; residual organic solvents (e.g., methanol, ethyl acetate) are separated on a capillary column and quantified using an FID detector, in accordance with ICH Q3C guidelines. |
| Melting Point | Capillary Melting Point Apparatus | A small amount of dried sample is packed into a melting point tube and heated at a controlled rate. The temperature range from initial melting to complete melting is recorded to assess crystalline purity and batch consistency. |
| Appearance and Color | Visual Comparison / Colorimeter | Observe solid color against a white background (should be white to off-white crystals). Standard color solutions or a colorimeter may be used for quantitative evaluation when necessary. |
| Loss on Drying (LOD) | Oven Weight Loss Method | The sample is dried under specified conditions (e.g., 105 °C) at atmospheric or vacuum pressure until constant weight. The percentage weight loss is calculated to reflect total volatile matter. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After digestion, determines residual levels of elements such as lead, cadmium, mercury, and arsenic, ensuring compliance with elemental impurity limits specified in ICH Q3D or relevant regulations. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR) | ¹H-NMR, ¹³C-NMR, and FT-IR are used to identify characteristic molecular peaks. Comparison with reference spectra confirms correct compound identity. |
| Chiral Purity (if applicable) | Chiral HPLC or Supercritical Fluid Chromatography (SFC) | If chiral centers are present, chiral columns are used to separate enantiomers. Enantiomeric excess (ee value) is determined to ensure optical purity meets synthesis or formulation requirements. |
Technical Specifications of 4-Chloro-4'-fluorobutyrophenone
| Test Item | Specification |
|---|---|
| Appearance | Yellow to brown liquid |
| Purity | ≥96.0% |
| Single impurity | ≤2.0% |
| Total impurities | ≤4.0% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-4'-fluorobutyrophenone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-4'-fluorobutyrophenone
Safety Information of 4-Chloro-4'-fluorobutyrophenone
| Pictograms |    |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-4'-fluorobutyrophenone
Industrial 4-Chloro-4'-fluorobutyrophenone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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