China Factory Direct
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| CAS number | 39065-95-7 |
| Product name | 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing novel fluorinated insecticides and fungicides | Used to construct fluorinated aniline active ingredients via nucleophilic substitution, coupling 4-(chlorodifluoro-methoxy)aniline with fluorinated acyl chlorides or isocyanates |
| Pharmaceuticals | Intermediate for synthesizing antiviral or antitumor drugs | Applied as an aromatic amine component in multistep synthesis, participating in coupling reactions or reductive amination to build the chlorodifluoro-methoxyaniline pharmacophore scaffold |
| Dyes & Pigments | Intermediate for synthesizing fluorinated azo dyes | Applied in diazotization followed by coupling with phenols or aromatic amines to produce fluorinated azo dyes exhibiting high stability and lightfastness |
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state (e.g., white to pale yellow crystalline or powder) to determine compliance with standard descriptions. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase chromatographic column with ultraviolet detection (e.g., 254 nm) to quantitatively determine the main component content, assessing sample purity (typically required ≥98.0%). |
| Related Substances / Impurities | HPLC or UPLC | Employ gradient elution procedures to separate and quantify potential process impurities, degradation products, etc., ensuring total impurities meet specified limits. |
| Moisture Content | Karl Fischer Titration | Determine water content using coulometric or volumetric Karl Fischer method, controlling within the range specified by pharmacopoeial or company standards (e.g., ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC-FID or GC-MS) | Follow ICH Q3C guidelines; use headspace injection or direct injection to quantitatively analyze residual organic solvents (e.g., methanol, ethyl acetate, DMF). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine residual levels of elements such as lead, cadmium, mercury, and arsenic, ensuring compliance with ICH Q3D or relevant pharmacopoeial limits for elemental impurities. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting temperature range for identification and assessment of crystal structure consistency (e.g., literature value approximately 75–78°C). |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) | ¹H-NMR, ¹³C-NMR, and ESI-MS or EI-MS are used to confirm molecular structure, ensuring the compound matches the intended target. |
| pH Value (if applicable) | pH Meter Measurement in Aqueous Solution | Dissolve the sample in water at a defined concentration and measure pH to assess acidity/basicity and its potential impact on subsequent formulation development. |
| Residue on Ignition | Gravimetric Method | After high-temperature incineration of the sample, weigh the residue to control inorganic salt impurities (typically required ≤0.1%). |
| Test Item | Specification |
|---|---|
| Appearance | Brown liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Danger |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.