METHYL ISOCYANOACETATE Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 39687-95-1 |
| Product name | METHYL ISOCYANOACETATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for METHYL ISOCYANOACETATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk METHYL ISOCYANOACETATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of METHYL ISOCYANOACETATE
| Industry | Application | Process |
|---|---|---|
| Organic Synthesis | Synthesis of pharmaceutical intermediates | Used as a key intermediate in the synthesis of anticancer agents and antibiotics, enabling construction of complex molecular frameworks via nucleophilic substitution or coupling reactions |
| Agrochemical Chemistry | Agrochemical intermediate | Applied in the synthesis of nitrile-containing insecticides or herbicides, leveraging the high reactivity of the isocyanide group in multistep synthetic pathways |
| Polymer Materials | Functional monomer | Employed as a functional monomer in polymerization reactions to introduce isocyanide groups, thereby enhancing thermal stability and reactivity of the resulting polymers |
| Biochemistry | Molecular probe | Utilized for labeling biomacromolecules or developing fluorescent probes, capitalizing on the specific reactivity of the isocyanide group |
| Pharmaceutical R&D | Synthesis of candidate compounds | Applied in new drug discovery to construct isocyanide-based compounds with defined biological activity, commonly introducing the isocyanide group via Mannich reactions or cycloaddition reactions |
Manufacturing Quality Control of METHYL ISOCYANOACETATE
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | Gas Chromatography (GC) | Utilizes a capillary column (e.g., DB-5 or HP-INNOWAX) with an FID detector, employing internal or external standard quantification. Samples must be diluted in an inert solvent (e.g., toluene) to prevent hydrolysis. Suitable for rapid determination of the main component and major organic impurities. |
| Water Content | Karl Fischer Titration | Measures trace water content using either coulometric or volumetric methods. Due to the tendency of isocyanoacetic acid methyl ester to react with water, forming carbamate by-products, rapid handling and use of anhydrous solvents (e.g., methanol/chloroform mixture) for dilution are required to avoid measurement errors. |
| Volatile Organic Impurities | Gas Chromatography-Mass Spectrometry (GC-MS) | Performs GC-MS analysis to identify and qualify/quantify potential degradation products (e.g., methylamine, methyl acetate, cyanide derivatives) and residual synthesis solvents (e.g., DMF, acetonitrile). Used for impurity profile control. |
| Confirmation of Isocyano Functional Group | Fourier Transform Infrared Spectroscopy (FT-IR) | Identifies characteristic absorption peaks: the isocyano group (–N≡C) exhibits a strong, sharp absorption at 2140–2160 cm⁻¹, distinguishing it from the cyano group (–C≡N, 2200–2260 cm⁻¹). Used for structural confirmation and assessment of functional group integrity. |
| Acidity/Basicity (pH) | Solution pH Measurement (Non-aqueous Medium) | Dissolve the sample in anhydrous ethanol or toluene and measure pH using a micro-electrode. Since the isocyano group readily hydrolyzes to produce acid, water content must be strictly controlled to avoid falsely acidic results. Used to evaluate storage stability. |
| Residual Solvents | GC-MS or Headspace GC | According to ICH Q3C guidelines, detects residual organic solvents such as acetone, ethanol, and dichloromethane potentially present from manufacturing. Headspace sampling is employed to prevent sample decomposition, suitable for high-purity pharmaceutical intermediates. |
| Thermal Stability | Thermogravimetric Analysis (TGA) / Differential Scanning Calorimetry (DSC) | Determines decomposition temperature and thermal behavior. Isocyanoacetic acid methyl ester typically begins decomposing at 80–120°C; TGA/DSC is used to assess thermal safety during storage and transportation. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After dry or wet digestion of the sample, measures heavy metal content (e.g., lead, cadmium, mercury, arsenic) to comply with pharmaceutical-grade standards (e.g., USP/EP), suitable for quality control of pharmaceutical intermediates. |
| Detection of Hydrolysis Products | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with UV detection (210–230 nm) to detect hydrolysis products such as methyl carbamate and methylamine. Commonly employed to monitor degradation products during accelerated stability studies. |
Technical Specifications of METHYL ISOCYANOACETATE
| Test Item | Specification |
|---|---|
| Appearance | Colorless to yellow clear liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.425–1.435 |
| Relative Density (20°C/25°C) | 1.070–1.090 g/cm³ |
| Odor | Characteristic pungent odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of METHYL ISOCYANOACETATE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of METHYL ISOCYANOACETATE
Packaging of METHYL ISOCYANOACETATE
Industrial METHYL ISOCYANOACETATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply