4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 397308-78-0 |
| Product name | 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pesticides | Herbicide intermediate | Serves as a key pyrimidine ring building block for synthesizing sulfonylurea herbicides (e.g., sulfometuron-methyl, bispyribac-sodium), enabling introduction of the sulfonylurea bridge via condensation with sulfonyl isocyanates or sulfonyl chlorides |
| Pharmaceuticals | Drug synthesis intermediate | Functions as a structural modification unit in pyrimidine nucleoside analogues for anticancer and antiviral agents; participates in coupling reactions to construct C-5 carboxylic acid derivatives, which undergo subsequent amidation or esterification |
Manufacturing Quality Control of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient HPLC with UV detection; identification and reporting per ICH Q3B guidelines. |
| Residual Solvents | GC-FID | Quantitative determination of volatile organic solvents (e.g., methanol, acetone, DMF) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Coulometric or volumetric titration based on the reaction of iodine with water in a controlled anhydrous medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic elements (Pb, Cd, As, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate ions using suppressed conductivity detection after aqueous extraction. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after high-temperature incineration at 700-800 C followed by weighing. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs under controlled heating. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in dispersed suspension using angular scattering intensity of laser light. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and path length. |
| Microbial Limits | Membrane Filtration / Plate Count | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, Salmonella) per USP <61> and <62>. |
Technical Specifications of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 245-249°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
Safety Information of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
Industrial 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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