(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 401564-36-1 |
| Product name | (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 401564-36-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 401564-36-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 401564-36-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate; precursor compound for the synthesis of the antidiabetic drug sitagliptin | Critical chiral intermediate in chiral resolution or asymmetric synthesis routes; used to construct the β-aminoamide structure of sitagliptin via hydrolysis, deprotection, and amination steps |
Manufacturing Quality Control of 401564-36-1
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-230 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient reversed-phase HPLC with UV detection; identification and quantification relative to main peak. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents (e.g., methanol, ethyl acetate, toluene) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the reaction of iodine with water in a pyridine-methanol solvent system. |
| Heavy Metals | ICP-MS | Multi-element detection and quantification of toxic elements (e.g., Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium residues (from catalytic steps) after microwave-assisted acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Residual Chlorides | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with conductivity detection. |
| Particle Size Distribution | Laser Diffraction | Determination of particle size distribution in dry powder form via light scattering pattern analysis. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying under controlled temperature and vacuum, reflecting volatile content including residual solvents and moisture. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial guidelines. |
Technical Specifications of 401564-36-1
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=99.0% (LC-MS) |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Optical Rotation | +15.0 to +17.0° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 401564-36-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 401564-36-1
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Industrial 401564-36-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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