8-Bromoguanosine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4016-63-1 |
| Product name | 8-Bromoguanosine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 8-Bromoguanosine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 8-Bromoguanosine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 8-Bromoguanosine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceutical Research | Used as a probe molecule in RNA modification studies to investigate the role of guanosine in transcription, translation, and RNA structure | Bromination via chemical synthesis, followed by use in in vitro enzymatic assays or cell culture systems to mimic natural nucleotide behavior |
| Molecular Biology | Employed as a modified nucleotide in primer or probe synthesis to enhance hybridization specificity or stability | Incorporated into oligonucleotides during solid-phase phosphoramidite synthesis as an 8-bromoguanosine derivative |
| Pharmaceutical Development | Serves as a structural precursor or intermediate for antiviral or anticancer nucleoside analogs | Further functionalized via nucleophilic substitution or coupling reactions to construct candidate drug molecules |
| Analytical Chemistry | Used as a chromatographic or mass spectrometric standard for detecting guanosine-related metabolites in biological samples | Prepared as a standard solution for calibration in quantitative analytical methods such as HPLC and LC-MS |
Manufacturing Quality Control of 8-Bromoguanosine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies 8-bromoguanosine by separation on a reversed-phase column and UV detection at ~254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., unreacted guanosine, bromination by-products) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identifies and quantifies volatile organic solvents (e.g., DMF, methanol, ethyl acetate) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration using iodine-based reagent reacting stoichiometrically with water. |
| Heavy Metals | ICP-MS | Measures trace metal contaminants (e.g., Pb, Cd, Hg, As) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| pH of Solution | Potentiometric pH Measurement | Measures hydrogen ion activity in aqueous solution using calibrated glass electrode and pH meter. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by ignition at 600-700 C followed by weighing of residual residue. |
| Optical Rotation | [alpha]D Measurement | Determines specific optical rotation using a polarimeter to confirm chiral integrity and identity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, verifying crystallinity and purity. |
| Microbial Limits | Membrane Filtration | Assesses total aerobic microbial count and absence of specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial methods. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample to determine volume-weighted particle size distribution using light scattering principles. |
Technical Specifications of 8-Bromoguanosine
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 195–199 °C |
| Optical Rotation | -30.0 to -26.0 deg (c=1, in water) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 8-Bromoguanosine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 8-Bromoguanosine
Packaging of 8-Bromoguanosine
Industrial 8-Bromoguanosine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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