5-Methyl-1H-pyrazole-3-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 402-61-9 |
| Product name | 5-Methyl-1H-pyrazole-3-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Methyl-1H-pyrazole-3-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Methyl-1H-pyrazole-3-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Methyl-1H-pyrazole-3-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing novel insecticides and fungicides | Participates in condensation reactions via the carboxylic acid group to construct pyrazole-based active molecular scaffolds |
| Pharmaceuticals | Intermediate for synthesizing anti-inflammatory and antitumor drugs | Serves as a heterocyclic carboxylic acid component in amide formation or esterification reactions to prepare drug lead compounds |
| Chemicals | Precursor for synthesizing functional dyes and optoelectronic materials | Couples with amines or alcohols via the carboxyl group to introduce pyrazole structural units |
Manufacturing Quality Control of 5-Methyl-1H-pyrazole-3-carboxylic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection and Physical Property Measurement | Observe sample color, state (white to off-white crystalline powder), solubility (e.g., in water, ethanol, DMF), and melting point range (literature value approximately 185–190°C). |
| Content Determination (Purity) | High-Performance Liquid Chromatography (HPLC) | Use C18 column with mobile phase of water-acetonitrile or methanol (containing 0.1% formic acid or phosphoric acid), UV detector at 210–230 nm for detection, external standard method for quantification of main component content, and assessment of impurity levels. |
| Impurity Profiling Analysis | HPLC-UV / HPLC-MS | Gradient elution used to separate potential organic impurities (e.g., unreacted starting materials, by-products, degradation products); mass spectrometry (MS) employed for structural identification of impurities, complying with ICH Q3B guidelines. |
| Water Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric Karl Fischer method; ensure water content remains below specification limit (e.g., ≤0.5%) to prevent hydrolysis or stability issues. |
| Melting Point | Melting Point Apparatus Measurement | Determine melting temperature using capillary tube method or automated melting point apparatus; compare with literature values (approximately 185–190°C) to assess polymorphic consistency and purity. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measure characteristic absorption peaks in the 200–300 nm range (e.g., λmax ≈ 220–240 nm) for preliminary identification and concentration estimation, supporting HPLC method validation. |
| Inorganic Impurities (e.g., Chloride, Sulfate) | Ion Chromatography (IC) or Colorimetric Methods | Ion chromatography used to detect anions such as chloride and sulfate; alternatively, classical colorimetric methods (e.g., silver nitrate, barium chloride) applied to control limits of inorganic impurities. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine lead, cadmium, mercury, arsenic, and other heavy metals using AAS or ICP-MS; comply with pharmacopoeial (e.g., USP/EP) total heavy metal limits (e.g., ≤10 ppm). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace GC-FID to detect residual solvents such as methanol, ethanol, acetone, DMF; control within permitted daily exposure (PDE) limits according to ICH Q3C guidelines. |
| Polymorph Analysis (Optional) | X-Ray Powder Diffraction (XRPD) | Used to confirm crystal structure and polymorphic consistency, ensuring physical property stability across batches—particularly important during formulation development. |
| pH Value (in Solution) | pH Meter Measurement | Prepare a solution at a defined concentration (e.g., 10 mg/mL), then measure pH (expected weak acidity, pH ≈ 4–6) to evaluate acidic characteristics and stability. |
Technical Specifications of 5-Methyl-1H-pyrazole-3-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178–182 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Methyl-1H-pyrazole-3-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Methyl-1H-pyrazole-3-carboxylic acid
Safety Information of 5-Methyl-1H-pyrazole-3-carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Methyl-1H-pyrazole-3-carboxylic acid
Industrial 5-Methyl-1H-pyrazole-3-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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