5-Fluoronicotinic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 402-66-4 |
| Product name | 5-Fluoronicotinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Fluoronicotinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Fluoronicotinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Fluoronicotinic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antitumor drug intermediates | Used as a key intermediate in constructing fluorinated nicotinic acid derivatives for bioactive pharmaceutical molecules |
| Pharmaceuticals | Antiviral drug development | Introduces fluorinated groups via coupling reactions to enhance metabolic stability and target selectivity |
| Agrochemicals | Insecticide and herbicide intermediates | Applied in synthesizing fluorinated heterocyclic agrochemicals to improve efficacy and environmental compatibility |
| Fine chemicals | Organic synthesis reagent | Participates in Suzuki coupling, esterification, and amidation reactions to prepare functional fluorinated derivatives |
| Materials science | Functional material precursor | Used to synthesize fluorinated organic materials with tailored optoelectronic properties |
Manufacturing Quality Control of 5-Fluoronicotinic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 230 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., 5-fluoronicotinamide, desfluoro analogs) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Ignition of sample at 700-800 C followed by weighing of residual inorganic ash after treatment with sulfuric acid. |
| Melting Point | Capillary Melting Point Apparatus | Thermal determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light induced by chiral molecules; used to confirm enantiomeric identity and absence of racemization. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity as a function of angle to derive volume-based particle size distribution. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Determination of hydrogen ion activity in a defined suspension (e.g., 1% w/v in water) using calibrated glass electrode. |
| Microbial Contamination | Membrane Filtration | Quantitative recovery and enumeration of aerobic microorganisms from a filtered sample solution cultured on soybean-casein digest agar. |
Technical Specifications of 5-Fluoronicotinic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 145-149°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Fluoronicotinic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Fluoronicotinic acid
Packaging of 5-Fluoronicotinic acid
Industrial 5-Fluoronicotinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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