trans-4-Hydroxy-L-proline methyl ester hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 40216-83-9 |
| Product name | trans-4-Hydroxy-L-proline methyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for trans-4-Hydroxy-L-proline methyl ester hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk trans-4-Hydroxy-L-proline methyl ester hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of trans-4-Hydroxy-L-proline methyl ester hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key intermediate in peptide drug synthesis | Used as an amino acid derivative monomer in solid-phase or solution-phase peptide synthesis to construct drug molecules containing hydroxyproline structures. |
| Pharmaceutical Chemicals | Chiral building block for chiral drug and bioactive molecule synthesis | Employed in stereoselective reactions leveraging its chiral center and hydroxyl functional group to synthesize drug intermediates with defined stereochemistry. |
| Pharmaceutical Chemicals | Intermediate in the synthesis of the antihypertensive drug perindopril | Serves as a key chiral intermediate in the synthesis of angiotensin-converting enzyme inhibitors (ACEIs), such as perindopril. |
| Scientific Research | Research on peptide and protein chemical modification | Applied as a reagent to introduce hydroxyproline residues, enabling studies on peptide secondary structure (e.g., collagen triple-helix conformation) and structure–activity relationships. |
Manufacturing Quality Control of trans-4-Hydroxy-L-proline methyl ester hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 200-220 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of impurities using gradient HPLC-UV; identification and quantification based on relative retention times and response factors. |
| Optical Rotation | Polarimetry | Measurement of specific optical rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Residual Solvents | GC-FID | Quantitative determination of residual solvents (e.g., methanol, dichloromethane) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine total water content based on stoichiometric reaction. |
| Heavy Metals | ICP-OES | Simultaneous multi-element detection of Pb, Cd, Hg, As, and other heavy metals after acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Chloride Content | Potentiometric Titration | Quantification of chloride ions using silver nitrate titrant and silver indicator electrode for endpoint detection. |
| pH (1% w/v aqueous solution) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous solution using calibrated glass electrode pH meter. |
| Loss on Drying | Gravimetric Method | Determination of volatile matter by measuring weight loss after drying at 105 C under controlled conditions for specified time. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) using membrane filtration followed by culture on selective media. |
Technical Specifications of trans-4-Hydroxy-L-proline methyl ester hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -31.0 to -27.0 deg (c=1, H2O) |
| Melting Point | 178 to 182 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of trans-4-Hydroxy-L-proline methyl ester hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of trans-4-Hydroxy-L-proline methyl ester hydrochloride
Safety Information of trans-4-Hydroxy-L-proline methyl ester hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of trans-4-Hydroxy-L-proline methyl ester hydrochloride
Industrial trans-4-Hydroxy-L-proline methyl ester hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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