China Factory Direct
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| CAS number | 40357-96-8 |
| Product name | 2-NITROTHIOPHENE-4-CARBOXYLIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as the core scaffold for synthesizing biologically active drug molecules (e.g., antimicrobial and antitumor agents) containing thiophene derivatives. |
| Agrochemicals | Agrochemical Intermediates | Applied in the synthesis of thiophene-containing agrochemical compounds, supporting construction and functionalization of heterocyclic derivatives. |
| Organic Synthesis | Synthetic Reagents and Building Blocks | Used in amidation or esterification reactions via the carboxyl group, or in reduction reactions via the nitro group, to prepare functionalized thiophene derivatives. |
| Materials Science | Precursors for Organic Optoelectronic Materials | Employed in synthesizing conjugated thiophene-based molecular structures required for organic semiconductor and optoelectronic materials. |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents (e.g., methanol, acetone, DMF) by gas chromatography with flame ionization detection, per ICH Q3C. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Chloride Content | Potentiometric Titration | Determination of chloride ions by titration with silver nitrate using a silver indicator electrode; endpoint detected via potential inflection. |
| Sulfated Ash | Gravimetric Analysis | Residue mass after incineration at 700-800 C following sulfuric acid treatment; measures inorganic impurities as sulfate salts. |
| Moisture Content | Karl Fischer Titration | Volumetric or coulometric determination of water content based on stoichiometric reaction between iodine and water in pyridine/methanol medium. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature range at which solid-to-liquid phase change occurs. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity to determine volume-based particle size distribution in dispersed dry or wet samples. |
| pH of Aqueous Suspension | pH Meter | Measurement of hydrogen ion activity in a defined aqueous suspension (e.g., 1% w/v) using calibrated glass electrode system. |
| Organic Volatile Impurities (OVI) | GC-MS | Identification and quantification of structurally unknown volatile organic impurities using gas chromatography coupled with mass spectrometry. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through a solution, indicating chiral purity and absence of racemization. |
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 178–182°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.