4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 405057-75-2 |
| Product name | 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of opioid analgesics (e.g., fentanyl derivatives) | Introduces the N-methyl group onto the piperidine ring via reductive amination or amidation, followed by deprotection or coupling to construct the target molecular scaffold |
| Pharmaceutical R&D | Used to build compound libraries featuring 4-substituted piperidine motifs | Serves as a modular building block in multistep organic synthesis, commonly undergoing condensation or nucleophilic substitution with carboxylic acids, alkyl halides, etc. |
| Chemical Reagents | Provides a protected 4-(methylamino)piperidine structural unit | Undergoes metal-catalyzed cross-coupling or electrophilic substitution while the amino group is CBZ-protected; the CBZ group is subsequently removed via hydrogenolysis |
Manufacturing Quality Control of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent; water reacts stoichiometrically with iodine in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal analysis after acid digestion; detection based on mass-to-charge ratio of metal isotopes with high sensitivity. |
| Chloride Impurity | Ion Chromatography | Separation of anions on ion-exchange column with suppressed conductivity detection; chloride quantified via calibration curve. |
| Residual Palladium | ICP-OES | After microwave-assisted acid digestion, palladium measured by optical emission at characteristic wavelength (e.g., 340.458 nm). |
| Optical Rotation | [alpha]D Measurement | Specific rotation determined using sodium D-line (589 nm) in solution; indicates enantiomeric purity and chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change; confirms identity and detects gross impurities. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after controlled heating under vacuum or nitrogen; reflects volatile content and residual solvents. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | pH electrode measurement of saturated aqueous suspension; indicates acidic/basic impurities affecting stability. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity versus angle to determine volume-based particle size distribution in dispersed slurry. |
Technical Specifications of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Safety Information of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Industrial 4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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