3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 40704-11-8 |
| Product name | 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Intermediate for the antidiabetic drug eplivanserin Serves as a key structural unit for constructing the pyrazole ring in the eplivanserin molecule. |
Multistep chemical synthesis Typically involves esterification, condensation, and cyclization steps; reacts with hydrazine or its derivatives to form the pyrazole ring, followed by coupling reactions to assemble the peptide backbone. |
| Pharmaceutical Chemicals | Building block for drug molecules Used to synthesize potential active pharmaceutical ingredients featuring a pyrazole scaffold (e.g., JNK inhibitors, GSK-3 inhibitors). |
Scaffold construction and modification Carboxyl group utilized in amidation or decarboxylative coupling reactions to generate diverse libraries of drug candidates. |
| Organic Synthesis | Reagent for nitrogen-containing heterocycle synthesis Serves as a precursor to pyrazole derivatives, introducing the 3-methyl-4-carboxylic acid pyrazole functional group. |
Functional group transformation Carboxylic acid group exploited in reduction (to alcohol), acid chloride formation (to acyl chloride), or decarboxylation to prepare other derivatives. |
| Agrochemicals | Agrochemical intermediate Used in synthesizing pyrazole-containing insecticides or fungicides. |
Chemical synthesis and derivatization Different pharmacophores (e.g., amide, ether linkages) are attached to the carboxyl group or nitrogen atoms to screen for biological activity. |
| Research Reagents | Analytical reagent and reference standard Used in pharmaceutical analysis, structural confirmation, and reaction mechanism studies. |
Preparation of certified reference materials High-purity compound obtained via purification (e.g., recrystallization, preparative HPLC) for use as chromatographic or NMR reference standards. |
Manufacturing Quality Control of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of impurities by gradient HPLC-UV; identification and quantification relative to main peak using response factors or reference standards. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents based on retention time and calibration curves. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent; water reacts stoichiometrically with iodine, sulfur dioxide, and base in methanol medium. |
| Heavy Metals | ICP-OES | Digestion followed by inductively coupled plasma optical emission spectrometry for simultaneous multi-element detection of Pb, Cd, Hg, As, and others. |
| Chloride Impurity | Ion Chromatography | Separation of anions on an ion-exchange column with suppressed conductivity detection; chloride quantified via external calibration. |
| Sulfate Impurity | Ion Chromatography | Same principle as chloride; sulfate eluted and detected using conductivity after suppression. |
| Residue on Ignition | Gravimetric Analysis | Ignition at 700-800 C to volatilize organic matter; residual inorganic ash weighed after cooling in desiccator. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature at which solid phase fully converts to liquid. |
| Appearance | Visual Inspection | Assessment under controlled white light against a white background for color, clarity, and presence of visible particles or foreign matter. |
| pH of Aqueous Solution | pH Meter | Measurement of hydrogen ion activity in a saturated aqueous suspension using calibrated glass electrode system. |
| Bulk Density | Graduated Cylinder Method | Mass of sample divided by its untapped volume in a standardized cylinder, reported in g/mL. |
Technical Specifications of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178–182°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Safety Information of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Industrial 3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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