Methyl 4-acetamido-2-methoxybenzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4093-29-2 |
| Product name | Methyl 4-acetamido-2-methoxybenzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 4-acetamido-2-methoxybenzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 4-acetamido-2-methoxybenzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 4-acetamido-2-methoxybenzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of antipyretic and analgesic drugs such as phenacetin | Used to prepare target drug molecules via reduction, hydrolysis, or further functional group transformations |
| Chemical Synthesis | Organic synthesis intermediate for constructing aromatic compounds bearing acetylamino and methoxy substituents | Serves as a key precursor in multistep syntheses, participating in coupling, substitution, or protection/deprotection reactions |
Manufacturing Quality Control of Methyl 4-acetamido-2-methoxybenzoate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Form | Visual Inspection, Melting Point Determination | Observe sample color and state (typically white to off-white crystalline powder), and determine melting point range (literature value approximately 130–135°C) to preliminarily assess purity and presence of impurities. |
| Assay (Active Ingredient) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with acetonitrile-water (containing 0.1% formic acid or phosphoric acid) as mobile phase and UV detection (wavelength 254 nm or 280 nm). Quantify using external or internal standard method to ensure the active ingredient content is ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Same HPLC conditions as assay, but with extended run time and reduced flow rate to detect potential degradation products (e.g., hydrolysis product methyl 4-amino-2-methoxybenzoate, deacetylated impurity, oxidation products). Impurity levels are controlled by area normalization or main component self-reference method, with total impurities ≤1.0%. |
| Residual Solvents | Gas Chromatography (GC) | Use DB-624 or HP-INNOWAX column with FID detector to test for residual solvents from manufacturing such as ethanol, ethyl acetate, and dichloromethane. Must comply with ICH Q3C limits. |
| Water Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric method. Water content should be ≤0.5% to prevent hydrolysis or stability issues during storage. |
| Melting Point | Capillary Melting Point Apparatus | Precisely determine melting point range (typical value 130–135°C) and compare with reference standard for identification and preliminary purity screening. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Prepare solution in ethanol or methanol (~10 μg/mL), measure absorption spectrum in the 200–400 nm range. Characteristic absorption peak around 270–280 nm used for qualitative confirmation and auxiliary purity assessment. |
| Inorganic Impurities (e.g., Chlorides, Sulfates) | Sulfate Test, Chloride Test | Perform limit tests according to pharmacopoeial general chapters (e.g., Chinese Pharmacopoeia appendices), applicable for pharmaceutical-grade control to ensure inorganic impurities meet drug substance standards. |
| Identification Tests | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare IR spectrum with reference standard. Characteristic peaks include: amide I band (~1650 cm⁻¹), ester carbonyl (~1720 cm⁻¹), methoxy group (~1250 cm⁻¹), aromatic C=C (~1600, 1580 cm⁻¹). |
| Identification Tests | Proton Nuclear Magnetic Resonance (¹H NMR) | Measure in DMSO-d₆ or CDCl₃. Characteristic signals include: acetyl methyl singlet (δ ~2.1 ppm), methoxy singlet (δ ~3.9 ppm), aromatic protons multiplet (δ 6.8–7.8 ppm), amide NH (δ ~9.5 ppm). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of heavy metals such as lead, cadmium, mercury, and arsenic per pharmacopoeial methods. Limit to ≤10 ppm to ensure product safety. |
Technical Specifications of Methyl 4-acetamido-2-methoxybenzoate
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | ≥98.0% |
| Single impurity | ≤0.5% |
| Total impurities | ≤1.0% |
| Loss on drying | ≤2.0% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 4-acetamido-2-methoxybenzoate
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| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 4-acetamido-2-methoxybenzoate
Safety Information of Methyl 4-acetamido-2-methoxybenzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 4-acetamido-2-methoxybenzoate
Industrial Methyl 4-acetamido-2-methoxybenzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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