Methyl 4-acetamido-5-chloro-2-methoxybenzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4093-31-6 |
| Product name | Methyl 4-acetamido-5-chloro-2-methoxybenzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 4-acetamido-5-chloro-2-methoxybenzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for non-steroidal anti-inflammatory drugs (NSAIDs), used in the synthesis of drugs such as loxoprofen | Organic synthesis, esterification |
| Pharmaceutical R&D | Structural modification and optimization of active pharmaceutical ingredients (APIs) for anti-inflammatory and analgesic agents | Structural modification, activity screening |
| Fine chemicals | High-value intermediate for the production of other benzoic acid derivatives | Catalytic reactions, purification |
Manufacturing Quality Control of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual inspection, Melting point determination | Observe sample color, crystalline form, and physical state; use a melting point apparatus to determine melting range and compare with standard reference material to assess purity and crystallinity. |
| Identification Test | Infrared Spectroscopy (IR), High-Performance Liquid Chromatography (HPLC) | IR: Confirm molecular structure by characteristic functional group absorption peaks (e.g., C=O, N-H, C-O-C, C-Cl); HPLC: Compare retention time with that of reference standard to confirm main component. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 chromatographic column, UV detector (254 nm or 280 nm), and external standard method for quantitative analysis. Calculate the percentage of main component, which should meet pharmacopoeia or enterprise standards (e.g., ≥98.0%). |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution program to detect possible degradation products (e.g., hydrolysis products, deacetylated products, chlorinated isomers), and control impurity limits based on the percentage of main component peak area (e.g., ≤1.0%). |
| Solvent Residue | Gas Chromatography (GC) | Use headspace or direct injection, with FID detector, to detect residual organic solvents such as ethanol, ethyl acetate, dichloromethane, etc., in accordance with ICH Q3C standards. |
| Moisture Content | Karl Fischer Titration | Determine trace water content using the iodine-sulfur dioxide-pyridine-methanol system. Control moisture content (e.g., ≤0.5%) to prevent hydrolysis or abnormal crystallization. |
| Chlorine Content | Ion Chromatography (IC) or Elemental Analysis | IC: Dissolve the sample and measure chloride ion concentration; Elemental Analysis: Use CHNCl analyzer to determine total chlorine content and verify the presence and proportion of chlorine atoms in the molecule, ensuring it matches theoretical values. |
| Heavy Metal Residues | Atomic Absorption Spectrometry (AAS) or ICP-MS | After ashing and acid digestion, determine the content of heavy metals such as lead, cadmium, mercury, and arsenic, which should comply with pharmacopoeia limits (e.g., Pb ≤ 5 ppm). |
| Solubility | Shaking Flask Method / Turbidity Method | Determine equilibrium solubility in different pH buffer solutions or solvents (water, ethanol, ethyl acetate), to evaluate suitability for formulation. |
| Particle Size Distribution (if solid API) | Laser Diffraction | Determine particle size distribution of powder, which affects dissolution rate and uniformity of solid dosage forms, suitable for injectable or oral solid formulations. |
| Microbial Limits (if applicable) | Plate Count Method, Membrane Filtration Method | Detect aerobic bacteria count, mold and yeast, and Escherichia coli, complying with non-sterile API microbial standards (e.g., USP/EP). |
Technical Specifications of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 142–146°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Safety Information of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Industrial Methyl 4-acetamido-5-chloro-2-methoxybenzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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