4-(METHYLAMINO)-3-NITROBENZOIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 41263-74-5 |
| Product name | 4-(METHYLAMINO)-3-NITROBENZOIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-(METHYLAMINO)-3-NITROBENZOIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-(METHYLAMINO)-3-NITROBENZOIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate in the synthesis of the antimalarial drug amodiaquine | Used to prepare the active pharmaceutical ingredient of amodiaquine via reduction, diazotization, and hydrolysis |
| Agrochemical Intermediates | Structural building block for synthesizing novel insecticides and herbicides | Serves as a nitroaniline-based building block in coupling or reductive alkylation reactions |
| Dye Intermediates | Used in the synthesis of azo dyes and functional lake pigments | Introduces chromophoric systems via diazotization-coupling reactions to enhance color fastness and light stability |
Manufacturing Quality Control of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | A reversed-phase C18 column is used with methanol-water or acetonitrile-water (containing 0.1% formic acid or phosphoric acid) as the mobile phase. Detection is performed using a UV detector at wavelengths between 250–280 nm. Quantification is achieved via external or internal standard methods, offering high selectivity and sensitivity, suitable for accurate determination of the active ingredient in both raw materials and finished products. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC) / Liquid Chromatography-Mass Spectrometry (LC-MS) | Gradient elution is employed to separate potential structurally related impurities (e.g., unreacted starting materials, oxidation products, demethylated compounds, nitro-reduced species). LC-MS provides molecular weight and fragment ion information for structural identification of impurities, meeting ICH Q3B requirements for impurity control. |
| Melting Point Determination | Melting Point Apparatus (Capillary Method) | In accordance with General Chapter 0612 of the Chinese Pharmacopoeia, the sample is packed into a capillary tube and heated gradually while observing the melting process. The typical melting range of 4-amino-3-nitrobenzoic acid is approximately 195–200°C, used for preliminary assessment of purity and crystalline form consistency. |
| Moisture Content | Karl Fischer Titration | Utilizes a quantitative reaction between water and an iodine-sulfur dioxide-pyridine-methanol system. Moisture content is determined by potentiometric or endpoint detection. This method is suitable for controlling trace moisture in active pharmaceutical ingredients (APIs), preventing hydrolysis or degradation affecting stability. |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | The sample solution is prepared in ethanol or methanol, and scanned across the wavelength range of 200–400 nm to identify the maximum absorption wavelength (λmax, typically around 260–270 nm). Used for qualitative identification and rapid concentration estimation (requires calibration). |
| Inorganic Impurities (e.g., Chlorides, Sulfates) | Methods from Chinese Pharmacopoeia General Chapters (Colorimetric Methods) | Samples are processed according to pharmacopoeial procedures and compared visually or instrumentally with standard solutions to control limits for chloride ions, sulfate ions, and other inorganic impurities, ensuring process cleanliness and product safety. |
| pH Value | pH Meter Method | The sample is dissolved in water at a specified concentration (e.g., 10 mg/mL), and the pH is measured using a calibrated pH meter. This test evaluates acidity/basicity and solubility behavior, providing indirect insight into purity. |
| Heavy Metal Testing | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Samples are processed according to pharmacopoeial heavy metal testing procedures (e.g., residue upon ignition), followed by measurement of lead, cadmium, arsenic, mercury, and other heavy metals to ensure compliance with ICH Q3D or pharmacopoeial limits. |
| Crystal Form Analysis | Fourier Transform Infrared Spectroscopy (FT-IR) or X-Ray Powder Diffraction (XRPD) | Identification of polymorphic forms is achieved through characteristic absorption peaks (FT-IR) or diffraction patterns (XRPD), ensuring physical property consistency across production batches, which may influence solubility and bioavailability. |
| Particle Size Distribution (if applicable) | Laser Diffraction or Microscopy | If the material is a powder or intended for formulation, particle size distribution must be controlled. A laser diffraction particle size analyzer is commonly used to ensure uniform mixing, compressibility, and overall performance in dosage form manufacturing. |
Technical Specifications of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to amber crystalline powder |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178–182 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.3% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
Safety Information of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-(METHYLAMINO)-3-NITROBENZOIC ACID
Industrial 4-(METHYLAMINO)-3-NITROBENZOIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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