4-chloro-7-Methoxyquinoline-6-carboxaMide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 417721-36-9 |
| Product name | 4-chloro-7-Methoxyquinoline-6-carboxaMide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-chloro-7-Methoxyquinoline-6-carboxaMide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-chloro-7-Methoxyquinoline-6-carboxaMide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthetic intermediate | Used to prepare quinoline-based compounds with antitumor activity; serves as a key intermediate in multistep organic synthesis |
| Biochemical research | Molecular probe construction | Functionalized for fluorescent labeling or target protein binding studies |
| Pesticide development | Potential active ingredient screening | Serves as a heterocyclic scaffold in the design and structural optimization of novel pesticide molecules |
Manufacturing Quality Control of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Physical Property Measurement | Observe the color, crystal form, and state (e.g., white or white crystalline powder), determine the melting point range (typically 220–230 °C according to literature), and ensure compliance with pharmacopoeia or internal company standards. |
| Identification | Infrared Spectroscopy (IR), High-Performance Liquid Chromatography (HPLC) Retention Time, Ultraviolet-Visible Spectroscopy (UV-Vis) | IR: Compare characteristic functional group absorption peaks (e.g., amide C=O at 1650–1680 cm⁻¹, aromatic C=C at 1580–1600 cm⁻¹); HPLC: Retention time matches that of reference standard; UV: Determine maximum absorption wavelength in ethanol or methanol (e.g., λ_max ≈ 280–300 nm). |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 column, mobile phase of methanol-water or acetonitrile-phosphate buffer solution (e.g., 40:60, v/v), and ultraviolet detector (280–300 nm). Calculate the main component content using external standard method, typically requiring ≥98.0%. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC-UV/MS) | Separate impurities using gradient elution, detect unknown impurity peaks; identify degradation products (e.g., hydrolysis products, dechlorinated compounds, oxidized species) using mass spectrometry (LC-MS), control single impurity ≤0.1%, total impurities ≤0.5% (per ICH Q3B). |
| Solvent Residues | Gas Chromatography (GC) | Use headspace or direct injection, with DB-624 or HP-INNOWAX columns to detect residual solvents (e.g., methanol, ethanol, acetonitrile, dichloromethane), meeting ICH Q3C limits. |
| Water Content Determination | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric methods, controlling water content ≤0.5% (may be relaxed to 1.0% depending on stability requirements), ensuring product stability and solubility. |
| Chlorine Content (Quantitative) | Ion Chromatography (IC) or Oxygen Bomb Combustion + Ion Selective Electrode | Convert the sample to chloride ions via oxygen bomb combustion, then measure Cl⁻ concentration using ion chromatography, or quantify using a chloride ion selective electrode, verifying that the chlorine content matches the theoretical value (theoretical Cl% ≈ 18.5%). |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After wet digestion, determine the levels of heavy metals such as lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg), complying with ICH Q3D or pharmacopoeia limits (e.g., Pb ≤10 ppm). |
| Microbial Limit (if applicable) | Microbial Counting Method, Control Organism Testing | If used as a pharmaceutical intermediate or active pharmaceutical ingredient, test for total aerobic bacteria, molds and yeasts, and E. coli, conforming to the microbial limit standards for non-sterile pharmaceuticals in the Chinese Pharmacopoeia. |
| Solubility and pH (Solution Properties) | Solubility Test, pH Meter | Determine solubility behavior in solvents such as water, ethanol, DMSO; measure pH of saturated solutions to evaluate acidity or alkalinity (amide groups are neutral, pH ≈6–8), for formulation compatibility reference. |
Technical Specifications of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-chloro-7-Methoxyquinoline-6-carboxaMide
Safety Information of 4-chloro-7-Methoxyquinoline-6-carboxaMide
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-chloro-7-Methoxyquinoline-6-carboxaMide
Industrial 4-chloro-7-Methoxyquinoline-6-carboxaMide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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