China Factory Direct
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| CAS number | 421-85-2 |
| Product name | Trifluoromethanesulfonamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate for antiviral agents, anticancer drugs, and protein kinase inhibitors | Participates in coupling reactions, sulfonamidation reactions, and other transformations to construct active molecular scaffolds containing the triflyl group |
| Agrochemicals | Key intermediate for high-efficiency insecticides, fungicides, and plant growth regulators | Introduces the triflylamino group via reaction with heterocyclic compounds or aromatic amines to enhance biological activity and metabolic stability |
| Materials Science | Functional monomer for high-performance polymers (e.g., polyimides, polysulfones) and additive for organic optoelectronic materials (e.g., OLED hole-transport layers) | Acts as a sulfonylation reagent for selective aromatic ring modification, or incorporates strong electron-withdrawing groups into condensation polymers (e.g., with diamines or dicarboxylic acids) to tune thermal stability and charge transport properties |
| Organic Synthesis | Strongly electron-withdrawing, highly stable amino protecting group and chiral auxiliary | Forms imines with aldehydes or ketones at low temperature, or undergoes N-alkylation followed by asymmetric catalytic reactions; subsequently removed under mild conditions (e.g., basic hydrolysis) |
| Test Item | Common Testing Methods | Method Overview |
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| Purity/Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 chromatographic column, with water-organic solvent (e.g., acetonitrile or methanol) as the mobile phase, and UV detection (typically at 200–220 nm) to measure the peak area of the main component. Purity is calculated using an external standard method or area normalization. |
| Gas Chromatography (GC) | Applicable for samples with good volatility and thermal stability. Uses polar or medium-polarity capillary columns, with FID or MS detectors for quantitative analysis of the main component and impurities. | |
| Related Substances (Impurities) | HPLC or GC | As above, by comparing with reference standards or system suitability solution, potential impurities (such as unreacted raw materials, by-products, degradation products, etc.) are identified and quantified. |
| Moisture | Karl Fischer Titration | Utilizes the quantitative reaction between iodine and sulfur dioxide in the presence of pyridine/imidazole with water. The moisture content is accurately determined by potentiometric or coulometric titration. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) | The sample is placed in a sealed headspace vial and heated to equilibrium. The gas phase is then sampled and analyzed by GC-FID or GC-MS to determine residual organic solvents (e.g., dichloromethane, toluene, ethanol). |
| Melting Point | Melting Point Apparatus | Uses a capillary method or digital melting point apparatus. The temperature range from initial melting to complete melting is determined according to pharmacopoeia specifications, to assess crystalline purity. |
| Appearance and Physical Properties | Visual Inspection | Observe the color, state (white or off-white crystalline powder), and presence of foreign matter of the sample. |
| pH Value (if prepared as a solution) | pH Meter Measurement | Prepare the sample as a solution of a certain concentration (e.g., 1%), and use a calibrated pH meter to measure its acidity or alkalinity, reflecting acidic impurities or hydrolysis conditions. |
| Ignition Residue/Ash Content | Gravimetric Method | After high-temperature ignition, the mass of the residual inorganic material is measured to assess the total amount of inorganic impurities. |
| Elemental Impurities (e.g., S, F, etc.) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Ion Chromatography (IC) |
ICP-MS is used for trace metal element detection; ion chromatography can be used to determine anion impurities such as fluoride and sulfate. |
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (NMR) |
| Water Content (KF) | <=0.5% |
| Melting Point | 78-82°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Identification (IR) | Consistent with reference spectrum |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.