China Factory Direct
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| CAS number | 424818-25-7 |
| Product name | N-T-BUTYL 3-NITROBENZENESULFONAMIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate for synthesizing antitumor agents (e.g., Bcl-2 inhibitor analogs) | Generates a sulfonamide anion upon reaction with a base (e.g., NaH or LiHMDS) under inert atmosphere, followed by condensation with aldehydes/ketones or participation in cyclization reactions |
| Agrochemical R&D | Structural modification unit for novel sulfonamide-based herbicides or plant growth regulators | Functions as a nitroaryl sulfonamide scaffold; active side chains are introduced via reduction, diazotization, or coupling reactions |
| Organic Synthesis | Multifunctional protecting reagent (N-tert-butyl-3-nitrobenzenesulfonyl, NBuS) for selective protection and deprotection of amines | Stable under mild basic conditions (e.g., K₂CO₃/MeOH); deprotection employs reductive systems such as Zn/AcOH or TiCl₃/THF to selectively cleave the N–S bond |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., acetone, methanol, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent where water reacts stoichiometrically to determine trace moisture content. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry for sub-pptr detection. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with suppressed conductivity detection. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate ions using anion-exchange column with suppressed conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic ash content by ignition at 700-800 C followed by weighing of residual non-volatile matter. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing the temperature range at which solid-to-liquid phase change occurs under controlled heating. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of sample against established reference standards under controlled lighting. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in dry or dispersed state via angular scattering pattern analysis of laser beam. |
| Bulk Density | Tap Density Tester | Determination of mass per unit volume after standardized mechanical tapping of a known powder mass in a graduated cylinder. |
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 128–132°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Identification (IR) | Conforms to reference spectrum |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.