4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 426844-51-1 |
| Product name | 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral catalyst ligand precursor for synthesizing fluorinated drug molecules | Used as a proline derivative in asymmetric catalytic reactions—such as Aldol reactions and Michael additions—to construct chiral centers, followed by deprotection or coupling |
| Pharmaceutical R&D | Structural building block for novel antitumor and antiviral candidate compounds | Employed as a fluorinated amino acid synthon in medicinal chemistry; incorporated into peptide chains via solid-phase or liquid-phase peptide synthesis (SPPS/LPPS) to enhance metabolic stability and membrane permeability |
| Organic Synthesis | Chiral auxiliary and asymmetric synthesis intermediate | Activated via amide bond formation to participate in cyclization, alkylation, or cross-coupling reactions; supplied as the hydrochloride salt for improved stability, handling, and weighing—typically neutralized with base to liberate the free amine prior to use |
Manufacturing Quality Control of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) | Confirm the presence of characteristic functional groups (e.g., amide, C–F bond) by comparing the sample's infrared absorption spectrum with a reference spectrum. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze the chemical shift, coupling constants, and integration area of hydrogen atoms in the compound to verify the molecular structure. | |
| Mass Spectrometry (MS or HRMS) | Determine molecular ion peaks and fragment ions to confirm molecular weight and elemental composition; high-resolution mass spectrometry can further verify the molecular formula. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase column and a UV detector (e.g., 210 nm or 220 nm) to quantify the main component, with external standard method or area normalization method for calculation. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate and quantify process impurities and degradation products under the same conditions as assay or with optimized gradient elution; impurity limits are typically set (e.g., ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Determine residual organic solvents (e.g., methanol, acetonitrile, dichloromethane) from synthesis or purification using headspace or direct injection, with polar or non-polar capillary columns and FID detector. |
| Water Content | Karl Fischer Titration | Determine water content in the sample using volumetric or coulometric methods, suitable for samples containing crystalline water or hygroscopic materials. |
| Residue on Ignition / Ash Content | Gravimetric Method | Weigh the inorganic residue after high-temperature ignition (typically 700–800°C) to assess total inorganic impurities. |
| pH Value | pH Meter Method | Prepare an aqueous solution of defined concentration (e.g., 1% w/v), and measure the pH using a calibrated pH meter to verify the hydrochloride form and purity. |
| Specific Optical Rotation | Polarimetry | Measure the optical rotation at a specified wavelength (typically sodium D-line, 589 nm) and temperature to verify L-configuration and optical purity. |
| Chloride Content | Ion Chromatography (IC) or Argentometry | Quantitatively determine chloride ion content to verify whether the salt-forming ratio conforms to the stoichiometric ratio (typically close to 1:1). |
Technical Specifications of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182 °C |
| Optical Rotation | +24.0 to +26.0 ° (c=1, H2O) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
Safety Information of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE
Industrial 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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