5-Chloropyrimidin-2-ol Hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 42748-90-3 |
| Product name | 5-Chloropyrimidin-2-ol Hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Chloropyrimidin-2-ol Hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Chloropyrimidin-2-ol Hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Chloropyrimidin-2-ol Hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthesis of antiviral drug intermediates | Used as a key intermediate in pyrimidine derivative synthesis to construct the active pharmaceutical ingredient (API) scaffold |
| Agrochemical R&D | Intermediate for fungicides and herbicides | Applied in the construction of nitrogen-containing heterocyclic compounds for developing novel agrochemicals |
| Organic Synthesis | Organic synthesis reagent | Employed in Suzuki coupling, nucleophilic substitution, and other reactions to prepare functionalized pyrimidine derivatives |
| Fine Chemicals | Precursor for functional materials | Incorporated as a chlorinated heterocyclic unit into polymer or functional material synthesis pathways |
Manufacturing Quality Control of 5-Chloropyrimidin-2-ol Hydrochloride
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe sample color and state (typically white to off-white crystalline powder), determine melting point range (literature value approximately 200–210 °C with decomposition), and evaluate flowability and hygroscopicity. |
| Assay (Active Ingredient) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-methanol or buffer (e.g., phosphate)-acetonitrile as the mobile phase. Detect using a UV detector (λ ≈ 254–280 nm) and calculate the assay by external standard method. Typically requires ≥98.0% purity. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Employ gradient elution to separate degradation products and synthesis-related impurities (e.g., unreacted 5-chloropyrimidin-2(1H)-one, dimers, etc.). Detection limit ≤0.1%. Quantify using area normalization or external standard method relative to the main component. |
| Water Content | Karl Fischer Titration | Determine free and bound (e.g., water of crystallization) moisture content using coulometric or volumetric methods. Limit typically ≤1.0% (adjustable based on hydration structure) to ensure product stability. |
| Chloride Ion Content | Ion Chromatography (IC) or Precipitation Titration | Ion chromatography: Separate Cl⁻ using an anion-exchange column with conductivity detection. Titration method: Titrate with AgNO₃ standard solution using potassium chromate as indicator; calculate chloride equivalents to confirm structural integrity of hydrochloride salt. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with a DB-624 capillary column and FID detector. Test for residual solvents such as ethanol, acetone, and acetonitrile in accordance with ICH Q3C guidelines, ensuring compliance with permissible limits. |
| Heavy Metals and Metal Ions | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample and analyze for heavy metals such as lead, cadmium, mercury, arsenic, and copper. Must meet pharmacopoeial limits (e.g., Pb ≤ 5 ppm) to ensure safety. |
| pH Value (aqueous solution) | pH Meter Measurement | Prepare a 1% aqueous solution and measure pH using a calibrated pH meter. Typical pH range is 2.0–4.0, reflecting the acidic nature of the hydrochloride salt. |
| Particle Size Distribution (if applicable) | Laser Diffraction or Microscopy | For powdered materials, measure D10, D50, and D90 particle sizes to ensure process consistency and dissolution performance (especially important for formulation development). |
| Melting Point | Melting Point Apparatus | Determine using capillary method or automated melting point instrument. Should match literature values (approximately 200–210 °C with decomposition), used for preliminary identification and purity assessment. |
| Infrared Spectrum (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare with reference spectrum to confirm characteristic functional group absorptions (e.g., C=O, C–Cl, N–H, NH₃⁺). Used for structural confirmation and counterfeit detection. |
Technical Specifications of 5-Chloropyrimidin-2-ol Hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210-215°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Chloropyrimidin-2-ol Hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of 5-Chloropyrimidin-2-ol Hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Chloropyrimidin-2-ol Hydrochloride
Industrial 5-Chloropyrimidin-2-ol Hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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