2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 43229-01-2 |
| Product name | 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate for the synthesis of the antiplatelet drug ticagrelor | Undergoes palladium-catalyzed coupling with amines, followed by reduction and cyclization to construct the triazolopyrimidine core structure of ticagrelor |
Manufacturing Quality Control of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) Proton Nuclear Magnetic Resonance (¹H NMR) High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) |
Confirm the compound structure and consistency with the target substance by characteristic absorption peaks in IR, chemical shifts and coupling constants in ¹H NMR, or molecular ion peaks and fragment ion information from HPLC-MS. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Using a reverse-phase C18 chromatographic column with methanol-water or acetonitrile-water as the mobile phase, and UV detection (usually at 254 nm or according to maximum absorption wavelength), quantitative determination of the main component content is carried out using external standard or internal standard methods. |
| Related Substances | High-Performance Liquid Chromatography (HPLC) | Using gradient or isocratic elution procedures to separate and detect impurities possibly generated during synthesis (such as unreacted raw materials, by-products, degradation products, etc.), and limit control is performed using area normalization method or main component self-reference method with correction factors. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH Q3C guidelines, GC-FID methods with headspace sampling or direct injection are used to detect residual amounts of organic solvents (such as dichloromethane, toluene, ethanol, etc.) used in production, ensuring compliance with limit requirements. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Constant Pressure Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, and calculate the percentage of mass loss to evaluate the content of moisture and volatile substances. |
| Melting Point | Capillary Melting Point Determination or Differential Scanning Calorimetry (DSC) | Determine the temperature range at which the sample transitions from solid to liquid, serving as an auxiliary indicator for purity and crystal form; higher purity results in a narrower melting range. |
| Water Content | Karl Fischer Titration (KFT) | Accurately determine the trace water content in the sample using volumetric or coulometric KF titration, particularly suitable for moisture-sensitive intermediates or APIs. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectrometry (AAS) | According to pharmacopoeia guidelines, detect heavy metal impurities such as lead, cadmium, mercury, and arsenic to ensure compliance with safety limits (referencing ICH Q3D). |
Technical Specifications of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
| Test Item | Specification |
|---|---|
| Appearance | White to Light yellow powder to crystal |
| Purity | ≥98.0% |
| Loss on drying | ≤1.0% |
| Melting point | 136~138°C |
| Single impurity | ≤1.0% |
| Total impurities | ≤2.0% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Safety Information of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
| Pictograms |    |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
Industrial 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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