4-Cyanopiperidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4395-98-6 |
| Product name | 4-Cyanopiperidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Cyanopiperidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Cyanopiperidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Cyanopiperidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the antidepressant paroxetine | Used to prepare paroxetine hydrochloride via reductive amination with 4-fluorobenzaldehyde, followed by cyclization |
| Pharmaceuticals | Structural building block for selective 5-HT6 receptor antagonists (e.g., idalopirdine) | Serves as a cyano-substituted piperidine heterocyclic fragment, participating in nucleophilic substitution or Suzuki coupling to construct the core scaffold |
| Pesticides | Synthesis intermediate for novel insecticides and plant growth regulators | Introduces nitrogen- and cyano-functionalized piperidine structures to enhance target binding affinity and metabolic stability |
| Materials Science | Monomer modifier for high-performance polyamide and polyurea functional polymers | Modified by hydrolysis of the nitrile group to carboxylic acid or reduction to amine, then grafted onto the polymer backbone to tailor polarity, thermal stability, and mechanical properties |
Manufacturing Quality Control of 4-Cyanopiperidine
| Test Item | Common Testing Method | Method Summary |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample color and state (e.g., white to off-white crystalline or powder) to determine if it meets the standard description. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Use a reverse-phase chromatographic column with an appropriate mobile phase to separate components. Quantify the purity of the main component using peak area normalization or external standard method. |
| Related Substances | HPLC (Gradient Elution) | Separate potential impurities using a gradient elution program. Identify and quantify impurities by comparing retention times and response values with reference standards. |
| Moisture | Karl Fischer Moisture Determination | Determine the moisture content in the sample using potentiometric or volumetric titration to ensure compliance with drying loss requirements. |
| Residual Solvents | Gas Chromatography (GC, Headspace Injection) | Use a capillary column and FID detector with headspace injection to quantify residual organic solvents (e.g., methanol, ethanol, ethyl acetate, etc.). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample and measure total amounts of elements such as lead, cadmium, mercury, and arsenic to assess compliance with pharmacopoeial or ICH Q3D limits. |
| Melting Point | Capillary Melting Point Determination | Use a digital melting point apparatus to measure initial and final melting temperatures, evaluating crystallinity and consistency. |
| pH Value (Solution) | pH Meter Measurement | Prepare the sample into a specified concentration aqueous solution and use a calibrated pH meter to measure its acidity or alkalinity, assessing stability or salt form effects. |
| Content Determination | HPLC External Standard Method or Non-Aqueous Titration | HPLC External Standard Method: Calculate content by comparison with reference standards; Non-Aqueous Titration: Titrate free base with perchloric acid in an anhydrous medium. |
| Chiral Purity (if applicable) | Chiral HPLC or Capillary Electrophoresis | Use chiral stationary phase columns or chiral additive buffer solutions to separate enantiomers and evaluate optical purity. |
Technical Specifications of 4-Cyanopiperidine
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
| Refractive Index (n20/D) | 1.475–1.485 |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Cyanopiperidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Cyanopiperidine
Packaging of 4-Cyanopiperidine
Industrial 4-Cyanopiperidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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