(4S)-4-hydroxy-L-proline hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 441067-49-8 |
| Product name | (4S)-4-hydroxy-L-proline hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (4S)-4-hydroxy-L-proline hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (4S)-4-hydroxy-L-proline hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (4S)-4-hydroxy-L-proline hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral auxiliaries and asymmetric synthesis building blocks for constructing proline-containing drug molecules (e.g., antiviral and anticancer candidates) | Used as a chiral template in solid-phase peptide synthesis or solution-phase coupling reactions, with hydroxyl and carboxyl groups participating in protection/deprotection and coupling steps |
| Pharmaceutical Intermediates | Key chiral starting material for synthesizing novel collagenase inhibitors and proline-derived therapeutics | Modified via selective O-alkylation, N-acylation, or C-functionalization, followed by cyclization or coupling to produce target active molecules |
| Biochemical Research | Cell culture additive and reference standard for studying proline metabolism pathways | Dissolved directly in serum-free culture medium to modulate collagen synthesis in fibroblasts or investigate hydroxyproline biosynthetic mechanisms |
Manufacturing Quality Control of (4S)-4-hydroxy-L-proline hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; quantification of L-isomer content relative to D-isomer and other stereoisomers. |
| Loss on Drying | Gravimetric (Thermogravimetry) | Mass loss measured after drying at 105 C for 2 hours under controlled humidity and airflow conditions. |
| Residue on Ignition | Gravimetric (Sulfated Ash) | Mass of inorganic residue remaining after ignition at 600 C following sulfuric acid treatment. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification after acid digestion, based on mass-to-charge ratio detection with isotopic resolution. |
| Related Substances | HPLC-UV | Detection and quantification of process-related impurities and degradation products using gradient HPLC with UV detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water via iodine-sulfur dioxide reaction in anhydrous methanol-based medium. |
| pH (1% aqueous solution) | pH Potentiometry | Measurement using calibrated glass electrode in a 1% w/v aqueous solution at 25 C. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 589 nm, corrected for concentration and path length. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic bacteria and fungi/yeasts after filtration, membrane transfer, and incubation on appropriate agar media. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity as a function of angle to determine volume-based particle size distribution in dry or dispersed state. |
Technical Specifications of (4S)-4-hydroxy-L-proline hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -33.3 to -26.2 deg (c=1, H2O) |
| Melting Point | 215 to 220 °C (decomposes) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (4S)-4-hydroxy-L-proline hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (4S)-4-hydroxy-L-proline hydrochloride
Safety Information of (4S)-4-hydroxy-L-proline hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (4S)-4-hydroxy-L-proline hydrochloride
Industrial (4S)-4-hydroxy-L-proline hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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