(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 444335-16-4 |
| Product name | (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 444335-16-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 444335-16-4 Supplier from China
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Industrial Applications of 444335-16-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral synthetic intermediate for the preparation of antibacterial agents (e.g., linezolid-class compounds) | Used as a key chiral building block—(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one—in subsequent amidation, cyclization, or coupling reactions to construct the oxazolidinone core structure, via asymmetric synthesis or chiral resolution |
Manufacturing Quality Control of 444335-16-4
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with the standard spectrum to confirm the presence of characteristic functional groups (such as C=O, C–F, C–Br, O–H, etc.). |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze the ¹H NMR spectrum to determine chemical shifts, coupling constants, and integration areas of hydrogen atoms, verifying molecular structure and stereochemistry (R configuration). | |
| High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Confirm the molecular weight and fragment ions of the target compound by combining retention time and mass-to-charge ratio (m/z), assisting in structural confirmation. | |
| Assay | High-Performance Liquid Chromatography (HPLC-UV) | Use reversed-phase HPLC with a UV detector (typically at 210–260 nm) to quantitatively determine the content of the main component using external or internal standard methods. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC-UV/DAD) | Separate the main peak and potential impurities (such as starting materials, intermediates, degradation products) using gradient elution, and quantify them based on a defined reporting threshold. |
| Enantiomeric Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use a chiral stationary phase column to separate (5R) and (5S) enantiomers, assessing optical purity (e.g., ee value ≥99%). |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Detect residual organic solvents (such as methanol, ethanol, dichloromethane, etc.) during synthesis or purification using headspace gas chromatography. |
| Water Content | Karl Fischer Titration | Determine the water content of the sample using volumetric or coulometric Karl Fischer titration, ensuring compliance with drying loss requirements. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range of the sample, used as a physical constant for auxiliary identification and purity assessment. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) |
Detect residual catalysts (such as Pd, Ni, etc.) or other heavy metal impurities, ensuring compliance with pharmacopoeia limits. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Drying at Constant Temperature |
Determine the total loss of volatile substances (including water and solvents) by drying to constant weight at a specified temperature (e.g., 105°C). |
Technical Specifications of 444335-16-4
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | -55.0 to -50.0° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 444335-16-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 444335-16-4
Packaging of 444335-16-4
Industrial 444335-16-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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