4-Nitrobenzyl chloroformate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4457-32-3 |
| Product name | 4-Nitrobenzyl chloroformate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Nitrobenzyl chloroformate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Nitrobenzyl chloroformate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Nitrobenzyl chloroformate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as an amino-protecting reagent, particularly for protecting the α-amino group of amino acids in peptide synthesis | In solid-phase or heterogeneous peptide synthesis, reacts with amino acids to form p-nitrobenzyloxycarbonyl (PNZ)-protected amino acid derivatives; the protecting group can subsequently be removed via hydrogenolysis or photolysis |
| Pharmaceuticals | Synthesis of prodrugs or pharmaceutical intermediates | Acts as an activated ester in acylation reactions to construct amide or ester linkages in specific drug molecules |
| Organic Synthesis | Introduction of the p-nitrobenzyloxycarbonyl (PNZ) protecting group | Reacts with primary or secondary amines under basic conditions to form stable carbamate-type protected products, suitable for protecting acid-sensitive substrates |
| Pesticides | Intermediate in the synthesis of certain pesticide active ingredients | Participates in constructing nitrogen-containing heterocyclic or aromatic amine structural units, enabling incorporation into target molecular frameworks via subsequent transformations |
| Fine Chemicals | Preparation of high-value fine chemicals | Functions as a selective acylating agent to achieve functional group transformation under mild conditions, suitable for late-stage modification of complex molecules |
Manufacturing Quality Control of 4-Nitrobenzyl chloroformate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., dichloromethane, methanol, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content in the sample. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator to measure free acid impurities. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and conductivity detection. |
| Heavy Metals | ICP-OES | Multi-element analysis after acid digestion; detection of Pb, Cd, Hg, As, and other regulated metals per ICH Q3D. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of visible particulates or discoloration under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Weight loss measured after drying under specified temperature and vacuum conditions to assess volatile content. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light to confirm chiral integrity and absence of racemization. |
| Residue on Ignition | Gravimetric Ashing | Determination of non-volatile inorganic residue after high-temperature incineration at 700-800 C. |
Technical Specifications of 4-Nitrobenzyl chloroformate
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78-82°C |
| Identification (NMR) | Conforms to reference spectrum |
| Identification (IR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Nitrobenzyl chloroformate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Nitrobenzyl chloroformate
Packaging of 4-Nitrobenzyl chloroformate
Industrial 4-Nitrobenzyl chloroformate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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