1,2:3,4-DI-O-ISOPROPYLIDENE-6-O-P-TOLYLSULFONYL-ALPHA-D-GALACTOSE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4478-43-7 |
| Product name | 1,2:3,4-DI-O-ISOPROPYLIDENE-6-O-P-TOLYLSULFONYL-ALPHA-D-GALACTOSE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4478-43-7
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4478-43-7 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4478-43-7
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a glycosylation intermediate for synthesizing complex oligosaccharides, glycosidic drugs, and antitumor antibiotics (e.g., doxorubicin derivatives) | Selectively protects the 6-hydroxyl group of D-galactose derivatives using p-toluenesulfonyl chloride as the sulfonylation reagent under anhydrous conditions, followed by acid-catalyzed ketalization with acetone to form an isopropylidene acetal—enabling construction of stereoselective glycosyl ring structures |
| Biochemistry | Used to synthesize model compounds of glycoproteins and glycolipids, and as substrates in glycosidase studies | Functions as a chiral building block, coupled to peptide chains or lipid scaffolds via enzymatic or chemical conjugation reactions to investigate carbohydrate recognition mechanisms and molecular interactions |
| Organic Synthesis | Used as a highly selective glycosyl donor for constructing β-galactosidic linkages | Undergoes Koenigs–Knorr-type glycosylation with alcohols or glycosyl acceptors under Lewis acid catalysis (e.g., BF₃·Et₂O) to achieve stereocontrol of the 1,2-cis configuration |
| Pharmaceutical R&D | Used in developing antiviral and antibacterial glycoside lead compounds | Serves as the core galactose-derived scaffold; subsequent deprotection and functional group modifications yield inhibitors targeting pathogen carbohydrate-binding proteins |
Manufacturing Quality Control of 4478-43-7
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 210-230 nm. |
| Identity | 1H NMR Spectroscopy | Confirmation of molecular structure through characteristic proton chemical shifts, coupling constants, and integration ratios in deuterated chloroform or DMSO-d6. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., unreacted starting materials, desulfonylated product, diastereomers) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents (e.g., acetone, toluene, ethyl acetate) based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water via iodine-sulfur dioxide reaction in anhydrous methanol-based reagent. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, based on atomic emission intensities at element-specific wavelengths. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions after aqueous extraction and filtration. |
| Sulfate Impurity | Ion Chromatography | Separation and conductivity detection of sulfate ions following sample dissolution and dilution in ultrapure water. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a sodium D-line (589 nm) polarimeter to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition detection by observing the temperature range over which solid-to-liquid phase change occurs under controlled heating. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after high-temperature incineration (600-750 C) and weighing of residual non-volatile matter. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample to determine volume-weighted particle size distribution based on light scattering patterns. |
Technical Specifications of 4478-43-7
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Optical Rotation | -64.0 to -65.0 (c=1, CHCl3) |
| Melting Point | 142 to 146 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 4478-43-7 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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