(R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 44864-47-3 |
| Product name | (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral drug intermediates for synthesizing antiplatelet agents (e.g., ticagrelor analogues) and β3-adrenergic receptor agonists | Chiral resolution or asymmetric catalytic hydroxylation to construct key chiral centers |
| Agrochemicals | Structural building blocks for novel chiral herbicides and fungicides | Used as chiral building blocks in heterocyclic coupling reactions to assemble biologically active molecules containing trifluoromethyl groups |
| Materials Science | Fluorinated chiral ligand precursors for preparing metal complexes used in asymmetric catalysis | Modified via esterification, amidation, or phosphination, then coordinated to transition metals (e.g., Rh, Ir) to form highly efficient chiral catalysts |
Manufacturing Quality Control of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with aqueous/organic solvent (e.g., methanol or acetonitrile) containing ion-pair reagents or low-pH buffer as the mobile phase, detected by UV detector (typically at 210–230 nm), quantified using external standard method for main component content. |
| Enantiomeric Purity (Chiral Purity) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Utilizes chiral stationary phase columns (e.g., Chiralpak AD-H, AS-H), normal-phase mobile phases (e.g., n-hexane/isopropanol) to separate (R) and (S) enantiomers, and calculates enantiomeric excess (e.e. value). |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyzes chemical shifts, coupling constants, and integration ratios of hydrogen (¹H NMR) and fluorine (¹⁹F NMR) atoms to confirm molecular structure and stereochemistry. |
| Purity and Impurity Profiling | Gas Chromatography-Mass Spectrometry (GC-MS) or Liquid Chromatography-Mass Spectrometry (LC-MS) | Used for identification and quantification of organic impurities; LC-MS is suitable for polar or thermally unstable compounds, providing molecular weight and fragmentation information to assist in structural elucidation. |
| Water Content | Karl Fischer Titration | Based on electrochemical titration principle, accurately measures water content in samples, suitable for trace moisture detection, ensuring product stability. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) | Follows ICH guidelines to detect organic solvents potentially residual from production (e.g., methanol, ethanol, ethyl acetate), quantified using FID detector. |
| Acid Value / Functional Group Analysis | Acid-Base Titration | Titration with standardized NaOH solution to determine carboxylic acid groups, with phenolphthalein or potentiometric endpoint indication, used to verify carboxyl group content matches theoretical values. |
| Appearance and Physical Properties | Visual Inspection and Melting Point Determination | Observe color and physical state; determine melting point range to assess crystallinity and purity (for solid substances). |
| Heavy Metals and Inorganic Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Detects heavy metal residues such as lead, arsenic, mercury, and cadmium, ensuring compliance with pharmacopeial limits for excipients or active pharmaceutical ingredients. |
Technical Specifications of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Optical Rotation | +15.0 to +17.0° (c=1, in methanol) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
Safety Information of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID
Industrial (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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