2-Bromo-5-nitropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4487-59-6 |
| Product name | 2-Bromo-5-nitropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-5-nitropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-5-nitropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-5-nitropyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of antitumor, antibacterial, or neuroactive drug molecules | Serves as a starting material for aromatic nucleophilic substitution or coupling reactions to construct complex heterocyclic structures |
| Agrochemical Intermediates | Synthesizing pyridine-containing insecticidal or herbicidal active ingredients | Undergoes reduction, substitution, and other steps to introduce nitro or bromo functional groups for derivatization into target compounds |
| Organic Synthesis | Functions as a versatile building block for constructing nitrogen-containing heterocyclic compounds | The bromo group enables Suzuki, Buchwald–Hartwig, and other cross-coupling reactions; the nitro group can be reduced to an amino group for further functionalization |
| Materials Science | Participates in the synthesis of optoelectronic materials or ligand molecules | Introduces conjugated structures or metal-coordinating groups via functional group transformation for use in OLEDs or catalytic systems |
Manufacturing Quality Control of 2-Bromo-5-nitropyridine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical State | Visual Inspection + Melting Point Determination | Observe sample color and state (typically yellow to orange crystals), determine melting point range (literature value ~108–112 °C), assess purity and crystallinity. |
| Content Assay (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column, with acetonitrile–water (containing 0.1% formic or phosphoric acid) as mobile phase, detected by UV detector (254–280 nm), quantified by external standard method, to evaluate main component purity (typically required ≥98%). |
| Impurity Analysis (Organic Impurities) | HPLC-UV / HPLC-MS | Separate possible impurities (e.g., unreacted starting material, de-brominated products, nitro-reduced byproducts) using gradient elution HPLC, UV detection limit is usually 0.1%, or combined with mass spectrometry (MS) for structural identification. |
| Bromine Content | Combustion Ion Chromatography (CIC) or ICP-OES | After oxygen bomb combustion or acid digestion, bromide ion concentration is determined by ion chromatography, or total bromine content is quantified by inductively coupled plasma optical emission spectrometry (ICP-OES), to verify stoichiometry. |
| Nitro Group Confirmation | Infrared Spectroscopy (FT-IR) | Confirm presence of nitro group via characteristic absorption peaks (asymmetric and symmetric stretching vibrations at ~1520 cm⁻¹ and 1350 cm⁻¹), for structural confirmation. |
| Residual Solvents | Gas Chromatography (GC-FID / GC-MS) | Detect possible residual organic solvents from manufacturing (e.g., DMF, ethanol, ethyl acetate), quantified according to ICH Q3C standards to ensure compliance with solvent residue limits. |
| Water Content | Karl Fischer Titration | Determine trace moisture content in the sample using coulometric or volumetric methods, control water content to ≤0.5% to prevent hydrolysis or stability issues during storage. |
| UV-Visible Absorption Spectrum | UV-Vis Spectrophotometry | Measure maximum absorption wavelength (λmax ≈ 270–290 nm) in ethanol or methanol for quick identification and concentration estimation, supporting HPLC method verification. |
| Melting Point | Capillary Melting Point Apparatus | Precisely measure melting range as a preliminary indicator of purity. A pure substance has a narrow melting range (≤2 °C), while a wide range suggests impurities. |
| Chlorides / Heavy Metals | Methods from Chinese Pharmacopoeia (e.g., Chloride Test, Heavy Metal Test) | Perform silver nitrate color reaction for chloride ion detection, or use thioacetamide method for heavy metal detection (calculated as lead, ≤10 ppm), suitable for API-grade control. |
Technical Specifications of 2-Bromo-5-nitropyridine
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 124–127 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-5-nitropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-5-nitropyridine
Packaging of 2-Bromo-5-nitropyridine
Industrial 2-Bromo-5-nitropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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