Ethyl difluoroacetate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 454-31-9 |
| Product name | Ethyl difluoroacetate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeReagent GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl difluoroacetate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl difluoroacetate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl difluoroacetate
| Industry | Application | Process Description |
|---|---|---|
| Pharmaceuticals | Pharmaceutical intermediates | Serves as a precursor for synthesizing fluorinated organic compounds in drug molecule construction |
| Pesticides | Pesticide synthesis | Used as a fluorinating agent or intermediate in the synthesis of insecticides and herbicides |
| Organic synthesis | Fluorinating reagent | Acts as a difluoromethylation reagent in nucleophilic substitution reactions |
| Materials science | Functional material preparation | Applied in the synthesis of fluorinated polymers or specialty resins |
| Analytical chemistry | Reference standard or reaction reagent | Used in gas chromatography analysis or as a reaction reference standard |
Manufacturing Quality Control of Ethyl difluoroacetate
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | Gas Chromatography (GC) | Separation using a capillary column with FID detection; the content of ethyl difluoroacetate is calculated by internal standard method or area normalization. Offers high sensitivity and good reproducibility, suitable for quantitative analysis of organic impurities. |
| Impurity Profile (Organic Impurities) | Gas Chromatography-Mass Spectrometry (GC-MS) | Following GC separation, a mass spectrometer detects and identifies unknown impurities, enabling identification of trace impurities such as ethyl fluoroacetate, ethyl acetate, and residual solvents. Suitable for comprehensive impurity profiling. |
| Moisture Content | Karl Fischer Titration | Quantitative reaction of water with an iodine-sulfur dioxide-pyridine-methanol system to determine trace moisture. Used to control moisture introduced via hygroscopicity or process residuals in ethyl difluoroacetate. |
| Acidity (Free Acid) | Acid-Base Titration (or Potentiometric Titration) | Titration with standard sodium hydroxide solution to determine free difluoroacetic acid or other acidic impurities. Potentiometric titration offers higher precision and is suitable for control of trace acidic impurities. |
| Boiling Point / Distillation Range | Boiling Point Apparatus or Distillation Method | Boiling point or distillation range determined according to pharmacopoeial or ASTM standards, verifying conformance with the theoretical boiling point of ethyl difluoroacetate (~85–88°C), used for preliminary purity assessment. |
| Appearance and Color | Visual Inspection + Platinum-Cobalt Colorimetric Method | Check visually for clarity and colorlessness; color is measured using platinum-cobalt standard solutions (in APHA units) to ensure absence of discoloration due to oxidation or degradation products. |
| Fluorine Content | Ion Chromatography (IC) or Oxygen Bomb Combustion with Ion-Selective Electrode | Sample is combusted in an oxygen bomb to convert fluorine into fluoride ions, which are then quantified by ion chromatography or fluoride ion-selective electrode. Used to verify whether fluorine content matches theoretical value (C₂H₃F₂O₂, theoretical F% ≈ 47.3%). |
| Residual Solvents | Headspace-Gas Chromatography (HS-GC) | Suitable for detecting organic solvents possibly remaining from manufacturing, such as ethanol, diethyl ether, and acetone. Headspace sampling avoids matrix interference and complies with ICH Q3C guidelines. |
| Density / Refractive Index | Densitometer / Abbe Refractometer | Density (theoretical value ~1.22 g/cm³) and refractive index (theoretical value ~1.36–1.38) measured at 20°C or 25°C. Used as physical constants for identity confirmation and purity assessment. |
Technical Specifications of Ethyl difluoroacetate
| Test Item | Specification |
|---|---|
| Appearance | Colorless to almost colorless clear liquid |
| Purity | >=98.0% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.345–1.355 |
| Relative Density (20°C/25°C) | 1.075–1.085 g/cm³ |
| Odor | Characteristic ester-like odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl difluoroacetate
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NMR Spectra of Ethyl difluoroacetate
Packaging of Ethyl difluoroacetate
Industrial Ethyl difluoroacetate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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