3-Fluoro-5-hydroxybenzonitrile Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 473923-95-4 |
| Product name | 3-Fluoro-5-hydroxybenzonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-Fluoro-5-hydroxybenzonitrile
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Fluoro-5-hydroxybenzonitrile Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Fluoro-5-hydroxybenzonitrile
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthesis of antitumor drug intermediates | Used as a key intermediate to construct fluorinated aromatic nitrile structures in active pharmaceutical ingredients; participates in coupling or nucleophilic substitution reactions |
| Agrochemical R&D | Intermediate for insecticide and herbicide synthesis | Applied in the preparation of novel fluorinated benzonitrile-based agrochemicals; hydroxyl and cyano groups are introduced via functional group transformation to optimize biological activity |
| Organic Synthesis | Building block for fluorinated aromatic compounds | Participates in carbon–carbon or carbon–heteroatom bond-forming reactions—including Suzuki coupling and Ullmann reactions—to construct complex molecular frameworks |
| Materials Science | Monomer for functional polymers or precursor for liquid crystal materials | Leverages its polar functional groups (—OH, —CN) and rigid aromatic ring structure in polymerization or structural modification to tune optoelectronic properties of materials |
Manufacturing Quality Control of 3-Fluoro-5-hydroxybenzonitrile
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity Determination | High-Performance Liquid Chromatography (HPLC) | Using a reverse-phase C18 column and UV detector (e.g., 254 nm), quantifying the main component purity via area normalization or external standard method. Applicable for assessing the content of the main component and impurity levels. |
| Related Substances/Impurity Analysis | HPLC (Gradient Elution) | Using gradient elution to separate the main peak from potential process-related impurities or degradation products; LC-MS can be used to assist in structural confirmation. The limit of quantification is typically ≤0.1%. |
| Moisture Content | Karl Fischer Titration | Determine moisture content using volumetric or coulometric methods, ensuring compliance with standards for loss on drying or moisture content (e.g., ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Head-space sampling or direct injection using capillary columns to separate common organic solvents (e.g., methanol, ethyl acetate), with quantification based on ICH Q3C limits. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR) | Confirm molecular structure integrity by comparing ¹H NMR, ¹³C NMR, and ¹⁹F NMR spectra with reference standards or theoretical data. |
| Melting Point Determination | Capillary Melting Point Method | Determine the temperature range at which the substance transitions from solid to liquid, used as a physical constant for preliminary identification and purity assessment (e.g., melting range ≤2°C). |
| Appearance and Characteristics | Visual Inspection | Observe color (should be white to off-white), crystal form, and presence of foreign matter, in accordance with pharmacopoeia or internal control standards. |
| Heavy Metals/Elemental Impurities | ICP-MS or Atomic Absorption Spectrometry | Detect elemental impurities such as Pb, As, Cd, Hg according to ICH Q3D guidelines, ensuring compliance with safety limits (typically at ppm level). |
| pH Value (if applicable) | pH Meter Measurement (in aqueous solution) | Determine pH value by preparing an aqueous solution of the sample at a certain concentration, used to assess its acid-base stability or whether acidic/basic impurities are introduced. |
| Loss on Drying | Drying to Constant Weight Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, calculate the percentage of weight loss, reflecting volatile components or adsorbed water content. |
Technical Specifications of 3-Fluoro-5-hydroxybenzonitrile
| Test Item | Specification |
|---|---|
| Appearance | Gray solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-Fluoro-5-hydroxybenzonitrile
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-Fluoro-5-hydroxybenzonitrile
Safety Information of 3-Fluoro-5-hydroxybenzonitrile
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 3-Fluoro-5-hydroxybenzonitrile
Industrial 3-Fluoro-5-hydroxybenzonitrile Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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