Chenodeoxycholic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 474-25-9 |
| Product name | Chenodeoxycholic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Chenodeoxycholic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Chenodeoxycholic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Chenodeoxycholic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of cholesterol gallstones, primary biliary cholangitis (PBC), and prevention of gallstone formation | Administered orally to inhibit hepatic cholesterol synthesis and promote bile acid secretion, thereby dissolving cholesterol gallstones and modulating bile composition |
| Pharmaceuticals | Key intermediate in the synthesis of ursodeoxycholic acid (UDCA) | Converted to ursodeoxycholic acid via chemical oxidation, reduction, or microbial transformation for use in hepatobiliary disease treatment |
| Pharmaceuticals | Raw material for preparing bile acid derivatives (e.g., obeticholic acid precursor) | Structurally modified via acylation, sulfonation, esterification, and other reactions to generate novel FXR receptor agonists |
| Cosmetics | Skin conditioning agent to improve keratin metabolism and barrier function | Incorporated into topical formulations such as serums and creams at typical concentrations of 0.1–1.0%, used in combination with stabilizers |
| Research | Reference standard and intervention reagent for bile acid metabolism studies in cellular and animal models | Administered via oral gavage or intraperitoneal injection at defined doses in vitro (e.g., HepG2 cells) or in murine cholestasis models |
Manufacturing Quality Control of Chenodeoxycholic acid
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Reverse-phase high-performance liquid chromatography (RP-HPLC) is employed, using a C18 column as the stationary phase. The mobile phase typically consists of methanol-water or acetonitrile-phosphate buffer, with UV detection at wavelengths between 200–254 nm. This method offers high sensitivity and excellent reproducibility, making it the most widely used quantitative analysis technique. |
| Purity Check | High-Performance Liquid Chromatography (HPLC) | The purity is assessed by comparing the peak area of the main component to that of impurities using either the self-reference method or external standard method. This approach effectively separates and quantifies related substances such as isomers and degradation products. |
| Related Substances (Impurity) Analysis | High-Performance Liquid Chromatography (HPLC) | Used to detect intermediates, isomers (e.g., ursodeoxycholic acid), oxidation products, and other impurities formed during synthesis. Gradient elution programs are commonly applied to enhance separation resolution, combined with UV or mass spectrometry (MS) for qualitative identification. |
| Acidity Test | Acid-Base Titration (Potentiometric or Indicator Titration) | Based on the acidity of its carboxylic acid group, the sample is titrated with standardized sodium hydroxide solution, using phenolphthalein as the indicator. The acid value is calculated to evaluate whether the acidity meets pharmacopeial requirements. |
| Moisture Content Determination | Karl Fischer Titration | A specialized method for determining trace amounts of water in samples, particularly suitable for moisture-sensitive pharmaceuticals. It provides accurate results and complies with the moisture limits specified in the Chinese Pharmacopoeia for raw materials. |
| Melting Point Determination | Microscopic Melting Point Apparatus or Capillary Method | By observing the melting behavior of the sample during heating, the melting range is determined. The typical melting point of ursodeoxycholic acid is approximately 190–192°C, which can be used for identification and preliminary purity assessment. |
| Ultraviolet-Visible Spectroscopy (UV-Vis) | UV Spectroscopy | Shows characteristic absorption peaks around 230–240 nm, useful for preliminary identification and auxiliary content determination; however, it is not suitable for precise quantification in complex mixtures. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Identifies functional groups (such as –COOH, –OH, C=O) through their characteristic absorption peaks, enabling structural confirmation and consistency verification of compounds. |
| Mass Spectrometry (MS) | Liquid Chromatography-Mass Spectrometry (LC-MS) | Enables high-sensitivity detection of trace impurities, metabolites, and structural elucidation. Particularly effective for qualitative and quantitative analysis of trace impurities in complex matrices. |
Technical Specifications of Chenodeoxycholic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 187~192°C |
| Optical Rotation | +9.0 to +13.0° (c=1, in ethanol) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Chenodeoxycholic acid
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NMR Spectra of Chenodeoxycholic acid
Packaging of Chenodeoxycholic acid
Industrial Chenodeoxycholic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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