N-METHYL-L-PROLINE MONOHYDRATE Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 475-11-6 |
| Product name | N-METHYL-L-PROLINE MONOHYDRATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for N-METHYL-L-PROLINE MONOHYDRATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-METHYL-L-PROLINE MONOHYDRATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-METHYL-L-PROLINE MONOHYDRATE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral synthetic intermediate | Used in the synthesis of biologically active peptides and drug molecules, serving as a chiral building block in asymmetric synthesis |
| Biochemistry | Peptide research | Employed as a non-natural amino acid in solid-phase peptide synthesis (SPPS) to study protein structure–function relationships |
| Organic synthesis | Catalyst ligand | Applied as a chiral catalyst or ligand precursor to control stereoselectivity in asymmetric catalytic reactions |
Manufacturing Quality Control of N-METHYL-L-PROLINE MONOHYDRATE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with UV detection | Quantitative determination based on peak area comparison against a certified reference standard using reversed-phase chromatography. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase to resolve N-methyl-L-proline from its D-enantiomer. |
| Water Content | Karl Fischer titration | Volumetric or coulometric titration measuring water via iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Residue on Ignition | Gravimetric analysis | Measurement of inorganic ash content after high-temperature incineration and weighing of residual material. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals following acid digestion and plasma emission spectroscopy. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and conductivity detection. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate ions using anion-exchange column and conductivity detection. |
| Related Substances | HPLC with UV detection | Detection and quantification of structurally related impurities (e.g., L-proline, N-methyl-D-proline, degradation products) using gradient elution. |
| pH (1% aqueous solution) | Potentiometric pH measurement | Determination of hydrogen ion activity in aqueous solution using calibrated glass electrode and pH meter. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength. |
| Loss on Drying | Thermogravimetric analysis | Weight loss measurement after drying under controlled temperature and vacuum or nitrogen flow to determine volatile content. |
| Microbial Limits | Membrane filtration followed by colony counting | Enumeration of aerobic mesophilic microorganisms using nutrient agar culture and incubation per pharmacopeial guidelines. |
Technical Specifications of N-METHYL-L-PROLINE MONOHYDRATE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 168-172°C |
| Optical Rotation | +23.0 to +27.0° (c=1, H2O) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of N-METHYL-L-PROLINE MONOHYDRATE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-METHYL-L-PROLINE MONOHYDRATE
Safety Information of N-METHYL-L-PROLINE MONOHYDRATE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-METHYL-L-PROLINE MONOHYDRATE
Industrial N-METHYL-L-PROLINE MONOHYDRATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply