3-bis(4-Methylbenzoyloxy)succinate) Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 477600-71-8 |
| Product name | 3-bis(4-Methylbenzoyloxy)succinate) |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-bis(4-Methylbenzoyloxy)succinate)
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-bis(4-Methylbenzoyloxy)succinate) Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-bis(4-Methylbenzoyloxy)succinate)
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral resolving agent for synthesizing chiral drug intermediates, such as levocitalopram | Used as a chiral auxiliary in chiral resolution processes to form diastereomeric salts with racemic piperidine amine compounds, enabling optical resolution via crystallization |
Manufacturing Quality Control of 3-bis(4-Methylbenzoyloxy)succinate)
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Using a C18 reversed-phase chromatography column, with water-acetonitrile or methanol as the mobile phase, under gradient or isocratic elution conditions. Detection is performed using a UV detector at 254 nm. Quantification is based on retention time comparison with standard substances and peak area calculation to determine the main component content, meeting pharmacopoeia requirements (e.g., ≥98.0%). |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Using the same HPLC system, detection wavelength is reduced (e.g., 210 nm) or a mass spectrometer is used to identify and quantify structure-related impurities such as unreacted raw materials, degradation products, or isomers. Impurity limits are calculated using the main component self-reference method or external standard method (usually ≤0.1%~0.5%). |
| Specific Rotation (Optical Purity) | Polarimetry | Dissolve the sample in a specified solvent (e.g., methanol or chloroform), and measure specific rotation [α]D²⁰ using a polarimeter at 20°C or 25°C. Compare with theoretical values (e.g., literature value for (2R,3R)-isomer) to confirm chirality purity and exclude racemic or diastereomeric contamination. |
| Moisture Content | Karl Fischer Titration | Quantitatively determine trace moisture using an iodine-sulfur dioxide-pyridine-methanol system through electrochemical titration or coulometric methods. Applicable to ester and amine-containing compounds; moisture content should be controlled within ≤0.5% to prevent hydrolysis or degradation. |
| Residual Solvents | Gas Chromatography (GC-FID/MS) | Use headspace or direct injection, with DB-624 or HP-INNOWAX columns to separate organic solvents such as methanol, acetonitrile, dichloromethane, etc. Detection is performed using FID. Residual solvent levels are controlled according to ICH Q3C standards. |
| Identification (Structural Confirmation) | Infrared Spectroscopy (IR) or Proton Nuclear Magnetic Resonance (¹H-NMR) | IR: Characteristic peaks such as ester carbonyl (1730–1750 cm⁻¹), aromatic C=C (1600, 1580 cm⁻¹); NMR: Confirm structure and stereochemistry by chemical shifts (e.g., aromatic protons δ 7.2–7.8 ppm, splitting patterns of protons adjacent to chiral centers). |
| Heavy Metals and Inorganic Impurities | Atomic Absorption Spectrometry (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample ashing or microwave digestion, detect heavy metals such as lead, cadmium, mercury, and arsenic. The content must meet ICH Q3D limits (e.g., Pb ≤10 ppm). |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting range of solid compounds for preliminary identification and purity assessment. For example: (2R,3R)-ester compound has a melting point of approximately 120–125°C, while (3R,4R)-piperidine amine hydrochloride melts at about 180–185°C (decomposes). |
| Solubility and Solution Clarity | Visual Inspection + Spectrophotometry | Prepare solutions in specified solvents (e.g., ethanol, DMSO). Check clarity visually, and if necessary, use UV-Vis spectrophotometry at 550 nm to measure turbidity, ensuring no insoluble particles or polymerization occurs. |
| Enantiomeric Purity (Enantiomeric Impurity) | Chiral HPLC or Supercritical Fluid Chromatography (SFC) | Separate enantiomers using chiral stationary phases (e.g., Chiralpak AD-H, OD-H) or SFC systems, and quantitatively detect non-target enantiomeric impurities (e.g., (2S,3S) or (3S,4S)), controlling them within ≤0.5%. |
Technical Specifications of 3-bis(4-Methylbenzoyloxy)succinate)
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Optical Rotation | +24.5° to +26.5° (c=1, in methanol) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-bis(4-Methylbenzoyloxy)succinate)
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NMR Spectra of 3-bis(4-Methylbenzoyloxy)succinate)
Safety Information of 3-bis(4-Methylbenzoyloxy)succinate)
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3-bis(4-Methylbenzoyloxy)succinate)
Industrial 3-bis(4-Methylbenzoyloxy)succinate) Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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