4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 479630-08-5 |
| Product name | 4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 479630-08-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 479630-08-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 479630-08-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for synthesizing selective 5-HT2C receptor agonists (e.g., lorcaserin analogs) and GABAA receptor modulators | Constructs the piperidine core via deprotection (removal of BOC), amination, cyclization, or coupling reactions in solid-phase or solution-phase multistep synthesis |
| Pharmaceutical R&D | Protected piperidine scaffold used in linker modules of proteolysis-targeting chimeras (PROTACs) | Serves as a modifiable site bearing an ethyl ester functional group; linker incorporation is achieved via ester hydrolysis followed by amidation, then coupled to both E3 ligands and target protein ligands |
| Fine Chemicals | Protected precursor of the piperidine ring in chiral drug synthesis, applied in stereoselective alkylation or reductive amination | Generates an enolate at low temperature (−78 °C) using a strong base (e.g., LDA), followed by α-alkylation with electrophiles (e.g., alkyl halides) |
Manufacturing Quality Control of 479630-08-5
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-220 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient reversed-phase HPLC with UV monitoring. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents based on retention time and flame ionization response relative to internal standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water via iodine-sulfur dioxide redox reaction in anhydrous methanol-based medium. |
| Residual Metals (e.g., Pd, Ni, Fe) | ICP-MS | Multi-element trace metal quantification by mass spectrometric detection of ionized atoms after microwave-assisted acid digestion. |
| Chiral Purity | Chiral HPLC-UV | Enantiomeric excess assessment using a chiral stationary phase and UV detection to resolve enantiomers. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid phase transition temperature range under controlled heating rate. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of visible particulates or foreign matter against established visual standards. |
| Loss on Drying | Gravimetric Method | Mass loss measurement after drying under specified temperature and vacuum conditions to determine volatile content. |
| Heavy Metals (Pb, Cd, As, Hg) | ICP-OES | Semi-quantitative screening and quantification of toxic elements following acid digestion and optical emission spectroscopy. |
| Residual Chloride | Ion Chromatography | Separation and conductivity detection of chloride ions after aqueous extraction and suppression. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution based on angular dependence of scattered laser light intensity. |
Technical Specifications of 479630-08-5
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 72-76 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 479630-08-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 479630-08-5
Packaging of 479630-08-5
Industrial 479630-08-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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