L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 482577-59-3 |
| Product name | L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 482577-59-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 482577-59-3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 482577-59-3
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing angiotensin II receptor blockers (ARBs) | Chemical synthesis |
| Pharmaceuticals | Raw material for preparing olmesartan medoxomil | Chemical synthesis |
Manufacturing Quality Control of 482577-59-3
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, condition, whether it is clumped, or has visible foreign matter under natural light or standard light source. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample with standard spectra to confirm consistency in functional groups and molecular structure. |
| Proton Nuclear Magnetic Resonance (¹H-NMR) | Determine the chemical structure by measuring hydrogen atom chemical shifts and coupling splitting. | |
| Mass Spectrometry (MS) | Determine the molecular ion peak ([M+H]+ or [M-H]−) to confirm the molecular weight of the target compound. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 chromatographic column and UV detector (e.g., 220–254 nm), with gradient or isocratic elution, using external or internal standard methods to determine the main component content. |
| Related Substances (Impurities) | HPLC (Gradient Elution) | Separate and detect process impurities and degradation products. Typically requires detection sensitivity up to 0.1%, using peak area normalization or external standard method for quantification. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual solvents such as methanol, ethanol, dichloromethane, ethyl acetate, and tetrahydrofuran based on ICH Q3C guidelines, using FID detector. |
| Moisture | Karl Fischer Titration | Precisely determine moisture content using volumetric or coulometric methods, suitable for hygroscopic compounds like hydrochlorides. |
| Melting Point | Melting Point Apparatus Method | Determine the melting range using capillary method, used to preliminarily judge purity and crystal form consistency. |
| Specific Rotation | Polarimeter Method | Determine specific rotation at a specified wavelength (e.g., sodium D-line, 589 nm) and solvent conditions, used to verify optical purity of L-valine configuration. |
| Chloride (Hydrochloride Form) | Ion Chromatography or Argentometry | Quantitatively determine chloride ion content to verify the salt formation ratio of hydrochlorides. |
| Sulfate | Turbidimetry or Ion Chromatography | Check for sulfate impurities to ensure no sulfate contamination from side reactions. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Oven Drying Method | Dry to constant weight at a specified temperature (e.g., 60–80°C) and calculate the weight loss to assess volatile components or adsorbed water. |
| Ignition Residue | Sulfation Residue Method | Weigh the inorganic residue after high-temperature incineration to evaluate total inorganic impurities. |
| Particle Size Distribution | Laser Particle Size Analysis | Used to evaluate particle size and distribution of the bulk drug substance, which affects solubility and processing performance in formulation. |
Technical Specifications of 482577-59-3
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | +16.0° to +20.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 482577-59-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 482577-59-3
Packaging of 482577-59-3
Industrial 482577-59-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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