Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 486460-00-8 |
| Product name | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for synthesizing GLP-1 receptor agonist antidiabetic drugs (e.g., liraglutide, semaglutide) | Multi-step organic synthesis involving introduction of a Boc protecting group and a trifluorophenyl moiety, followed by asymmetric hydrogenation or enzymatic resolution to achieve high optical purity; subsequent deprotection and coupling to the peptide chain |
Manufacturing Quality Control of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical form (e.g., white to off-white crystalline powder), presence of foreign matter, or moisture absorption and caking to preliminarily assess whether the physical state meets specifications. |
| Identification | Infrared Spectroscopy (IR) | Compare infrared absorption spectra with those of reference standards by analyzing characteristic peaks (e.g., C=O stretching vibration of Boc group, O–H and C=O of carboxylic acid, C–F bonds in aromatic rings) to confirm structural consistency. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts, coupling constants, and integration areas of hydrogen atoms to verify the presence and configuration of specific functional groups (e.g., Boc, trifluorophenyl, protons adjacent to chiral centers). | |
| Related Substances / Impurities | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase chromatographic columns (e.g., C18) with UV detection (e.g., 210–220 nm) to detect the main component and related impurities (e.g., de-Boc products, enantiomers, degradation products), and calculate impurity levels. |
| Enantiomeric Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separate R and S isomers using a chiral stationary phase column; determine enantiomeric excess (ee%) to ensure the (R)-configuration purity meets requirements (typically ≥99%). |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Quantify the main component content using external standard method or area normalization method via calibration curves, ensuring the active pharmaceutical ingredient purity meets specifications (e.g., ≥98.0%). |
| Water Content | Karl Fischer Titration | Determine moisture content using either volumetric or coulometric Karl Fischer titration, controlling water level within acceptable limits (e.g., ≤0.5%) to prevent hydrolysis or instability. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH Q3C guidelines, use headspace injection or direct injection with GC-FID/GC-MS to detect residual organic solvents (e.g., methanol, ethyl acetate, dichloromethane) from synthesis or purification processes. |
| Melting Point | Capillary Melting Point Determination | Determine the melting temperature range as a physical constant for auxiliary identification and to reflect crystal form and purity (expected melting point range should match literature or reference standards). |
| pH (Solution) | pH Meter Measurement | Dissolve the sample in a specified concentration of aqueous solution or buffer, then measure pH to evaluate acidity/basicity and indirectly assess the integrity of carboxylic acid groups. |
| Specific Rotation | Polarimeter Measurement | Measure optical rotation at a specified wavelength (e.g., 589 nm, sodium D line) and concentration to verify chirality and optical purity—critical for confirming the (R)-configuration. |
Technical Specifications of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow powder to crystal |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +24.6 to +32.2 deg (c=1, in 1M HCl) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Safety Information of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Industrial Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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