3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 486460-21-3 |
| Product name | 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 486460-21-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 486460-21-3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 486460-21-3
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of pharmaceutical intermediates | Organic synthesis reactions |
| Agrochemicals | Preparation of agrochemical active ingredients | Coupling and cyclization reactions |
| Materials Science | Production of functional fluorinated compounds | Fluorination and substitution reactions |
| Chemical Research | Laboratory reagent | Multistep organic synthesis |
Manufacturing Quality Control of 486460-21-3
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR) High-Performance Liquid Chromatography (HPLC) Retention Time Comparison |
Confirm molecular structure via IR characteristic absorption peaks, ¹H NMR chemical shifts and coupling constants; or use HPLC under specific chromatographic conditions to compare retention times with reference standards for rapid identification. |
| Assay (Content Determination) | High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV) | Utilize a reversed-phase C18 column with a mobile phase of methanol/acetonitrile and buffer aqueous solution, detected by UV detector (typically 210–230 nm). Quantify the main component content using external standard method, suitable for purity determination of active pharmaceutical ingredients. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) or Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Employ gradient elution to separate the main component from potential process impurities and degradation products. Use DAD for peak purity assessment; when necessary, combine with mass spectrometry (LC-MS) to identify unknown impurity structures, ensuring control of individual and total impurity levels within specified limits. |
| Residual Solvents | Headspace Gas Chromatography with Flame Ionization Detection (HS-GC-FID) | Following ICH Q3C guidelines, use headspace injection with capillary columns for separation and FID detection to quantify residual organic solvents (e.g., methanol, dichloromethane, ethyl acetate), ensuring compliance with safety thresholds. |
| Water Content | Karl Fischer Titration | Apply either volumetric or coulometric Karl Fischer titration to accurately determine moisture content, suitable for moisture-sensitive fluorinated heterocyclic compounds. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Constant Temperature Drying at Atmospheric Pressure | Dry samples at a specified temperature (e.g., 105°C) until constant weight is achieved, measuring mass loss to assess volatile components and adsorbed water content. |
| Melting Point | Capillary Melting Point Method or Differential Scanning Calorimetry (DSC) | Determine purity by observing the melting temperature range; high-purity samples exhibit narrow melting ranges. DSC provides more precise data on melting enthalpy and phase transition information. |
| Elemental Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Complying with ICH Q3D guidelines, detect potential catalyst residues (e.g., Pd, Ni) with high sensitivity and capability for simultaneous multi-element analysis. |
Technical Specifications of 486460-21-3
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 142–146 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 486460-21-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 486460-21-3
Packaging of 486460-21-3
Industrial 486460-21-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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