5-Chloro-1-methyl-4-nitroimidazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4897-25-0 |
| Product name | 5-Chloro-1-methyl-4-nitroimidazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Chloro-1-methyl-4-nitroimidazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Chloro-1-methyl-4-nitroimidazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Chloro-1-methyl-4-nitroimidazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of antiparasitic agents (e.g., metronidazole derivatives) and antibacterial compounds | Serves as a precursor to nitroimidazole compounds, enabling nucleophilic substitution or reduction reactions to construct the active molecular scaffold |
| Pesticide Development | Structural building block for insecticidal or fungicidal lead compounds | Optimizes biological activity through functional group modification (e.g., chlorine substitution, nitro group reduction) |
| Organic Synthesis | Building block for imidazole-containing functional molecules (e.g., ligands, ionic liquids) | Leverages the reactivity of the chlorine and nitro groups in cross-coupling or cyclization reactions |
Manufacturing Quality Control of 5-Chloro-1-methyl-4-nitroimidazole
| Milestone | Common Testing Methods | Method Overview |
|---|---|---|
| Major Component Content | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column, with a mobile phase of methanol-water or acetonitrile-phosphate buffer. The UV detector is used at 254–280 nm wavelength for detection. Quantification is performed using external or internal standard methods, offering high resolution and accuracy. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC-UV/DAD) | Gradient elution is used to separate potential process impurities (such as unreacted raw materials, by-products, and degradation products). The DAD detector provides spectral information for qualitative and quantitative analysis of impurities, in compliance with ICH Q3B guidelines. |
| Nitro Group Confirmation | Fourier Transform Infrared Spectroscopy (FT-IR) | Characteristic absorption peaks (e.g., ~1530 cm⁻¹ and ~1350 cm⁻¹ for asymmetric and symmetric stretching vibrations of nitro groups) are used to confirm the presence of nitro groups, supporting structural verification and batch consistency comparison. |
| Chlorine Content | Combustion Ion Chromatography (CIC) or Oxygen Bomb Combustion + Ion Chromatography | After oxygen bomb combustion, chlorine is converted into chloride ions, which are then quantified using ion chromatography to determine the chlorine content. This ensures that the actual chlorine content matches the theoretical value (theoretical Cl content ≈ 32.5%). |
| Solvent Residues | Gas Chromatography (GC-FID/MS) | Based on ICH Q3C guidelines, this method detects residual organic solvents (such as DMF, ethanol, and acetone) from the production process. Capillary columns are used for separation, and FID or MS detectors are employed to ensure compliance with solvent limits. |
| Moisture Content | Karl Fischer Titration | This method quantitatively reacts water with an iodine-sulfur dioxide-pyridine-methanol system. The moisture content is determined using either coulometric or volumetric methods, ensuring it remains ≤0.5% to prevent hydrolysis or stability issues. |
| Melting Point | Melting Point Apparatus | The melting point range of the pure substance (literature value approximately 110–114°C) is measured using a digital melting point apparatus. A narrow melting range (≤2°C) indicates high purity. |
| UV Absorption Characteristics | UV-Vis Spectrophotometry | A solution is prepared in methanol or acetonitrile, and the maximum absorption wavelength (λmax ≈ 260–275 nm) is measured. This is used to establish a standard curve, confirm structural characteristics, and assist in content determination. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, heavy metals such as lead, cadmium, mercury, and arsenic are analyzed using AAS or ICP-MS. This ensures compliance with pharmacopoeia or ICH Q3D limits for heavy metals (e.g., Pb ≤10 ppm). |
| Polymorphic Form and Crystallinity (optional) | X-ray Powder Diffraction (XRPD) | This method confirms the consistency of the polymorphic form of the active pharmaceutical ingredient, avoiding changes in solubility and stability due to polymorphic variations, especially for high-purity APIs requiring polymorphic control. |
Technical Specifications of 5-Chloro-1-methyl-4-nitroimidazole
| Test Item | Specification |
|---|---|
| Appearance | White to orange to green crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 128–132°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Chloro-1-methyl-4-nitroimidazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Chloro-1-methyl-4-nitroimidazole
Safety Information of 5-Chloro-1-methyl-4-nitroimidazole
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Chloro-1-methyl-4-nitroimidazole
Industrial 5-Chloro-1-methyl-4-nitroimidazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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