1-methyl-1,2,3,4-tetrahydroisoquinoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 4965-09-7 |
| Product name | 1-methyl-1,2,3,4-tetrahydroisoquinoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-methyl-1,2,3,4-tetrahydroisoquinoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-methyl-1,2,3,4-tetrahydroisoquinoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-methyl-1,2,3,4-tetrahydroisoquinoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Synthesis of pharmaceutical intermediates | Serves as a key structural scaffold for constructing tetrahydroisoquinoline-based drug molecules, e.g., in the production of smooth muscle relaxants or cardiovascular agents. |
| Pharmaceutical Industry | Chiral drug synthesis | Used as a racemic substrate in chiral resolution or asymmetric synthesis to produce enantiomerically pure pharmaceutical intermediates. |
| Chemical Industry | Fine chemical synthesis | Applied in the synthesis of quaternary ammonium compounds, surfactants, or other functional organic compounds. |
| Research Sector | Organic synthesis building block | Leverages its nitrogen-containing heterocyclic structure in N-alkylation, acylation, or electrophilic aromatic substitution reactions to construct more complex heterocyclic compounds. |
Manufacturing Quality Control of 1-methyl-1,2,3,4-tetrahydroisoquinoline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 220-280 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, toluene, ethyl acetate) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, with detection at sub-ppt levels. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Ignition at 500-600 C followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Appearance | Visual Inspection | Assessment of color and physical state (e.g., white to off-white crystalline powder) against established reference standards. |
| pH of Aqueous Solution | pH Meter | Measurement of hydrogen ion activity in a defined aqueous suspension or solution using calibrated electrode. |
| Residue on Ignition | Gravimetric Analysis | Weighing of non-volatile residue remaining after ignition at 700-800 C, reflecting inorganic impurities. |
Technical Specifications of 1-methyl-1,2,3,4-tetrahydroisoquinoline
| Test Item | Specification |
|---|---|
| Appearance | Pale-red liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Conforms to reference standard |
| Refractive Index (n20/D) | 1.575–1.585 |
| Relative Density (20°C/4°C) | 1.020–1.040 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-methyl-1,2,3,4-tetrahydroisoquinoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-methyl-1,2,3,4-tetrahydroisoquinoline
Safety Information of 1-methyl-1,2,3,4-tetrahydroisoquinoline
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-methyl-1,2,3,4-tetrahydroisoquinoline
Industrial 1-methyl-1,2,3,4-tetrahydroisoquinoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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