4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 496786-98-2 |
| Product name | 4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 496786-98-2
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 496786-98-2 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 496786-98-2
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Boronic ester intermediates for synthesizing piperidine-piperazine-containing targeted small-molecule drugs (e.g., kinase inhibitors) | Used in Suzuki-Miyaura cross-coupling reactions |
| Pharmaceutical R&D | Construction of nitrogen-containing heterocyclic compound libraries for high-throughput screening of antitumor and anti-inflammatory agents | Applied in solid-phase or solution-phase combinatorial synthesis |
| Fine Chemicals | High-purity pinacol boronate-protected piperazine-piperidine heterocyclic building blocks for multistep sequential functional group transformations | Subject to selective deprotection (under acidic conditions), followed by acylation, alkylation, or coupling |
Manufacturing Quality Control of 496786-98-2
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-230 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification via retention time matching and threshold-based reporting. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on calibrated external standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Heavy Metals | ICP-MS | Quantitative determination of elemental impurities (e.g., Pb, Cd, Ni, Pd) by mass spectrometry after acid digestion and dilution. |
| Residual Boron | ICP-OES | Determination of total boron content by atomic emission spectroscopy following microwave-assisted acid digestion. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20 C and sodium D-line (589 nm) to assess chiral integrity. |
| Residual Palladium | ICP-MS | Targeted quantification of palladium from catalytic residues using isotope-dilution or external calibration after digestion. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs under controlled heating rate. |
| Residual tert-Butyl Alcohol | GC-FID | Quantification of residual t-butanol by headspace GC-FID using internal standard calibration. |
Technical Specifications of 496786-98-2
| Test Item | Specification |
|---|---|
| Appearance | Off-white to white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 496786-98-2
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 496786-98-2
Packaging of 496786-98-2
Industrial 496786-98-2 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply