China Factory Direct
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| CAS number | 499-81-0 |
| Product name | 3,5-Pyridinedicarboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of the antitubercular drug pyrazinamide | Used to prepare pyrazinamide via cyclization and hydrolysis reactions with ammonia |
| Agrochemicals | Key structural building block for synthesizing novel herbicides and plant growth regulators | Employed as a ligand in the design and synthesis of metal-complex agrochemicals |
| Materials Science | Organic ligand for preparing metal–organic frameworks (MOFs) | Coordination assembly with transition metal ions (e.g., Cu²⁺, Co²⁺) under solvothermal conditions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Acid-Base Titration | Quantifies 3,5-pyridinedicarboxylic acid by titration with standardized NaOH using phenolphthalein or potentiometric endpoint detection. |
| Moisture Content | Karl Fischer Titration | Determines water content via coulometric or volumetric reaction between water and iodine in a pyridine-methanol solvent system. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic impurities by ignition at 700-800 C and weighing the residual ash. |
| Heavy Metals | ICP-OES | Quantifies trace metal contaminants (e.g., Pb, Cd, Hg, As) after acid digestion by measuring element-specific emission intensities. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using an anion-exchange column and conductivity detection. |
| Sulfate Impurity | Barium Sulfate Gravimetry | Precipitates sulfate as BaSO4 under controlled pH and temperature, followed by filtration and weighing. |
| Related Substances | HPLC-UV | Separates and detects structurally related impurities (e.g., mono-acids, esters, isomers) using reversed-phase C18 column and UV detection at 254 nm. |
| Melting Point | Capillary Melting Point Determination | Measures temperature range at which solid transitions to liquid using calibrated capillary apparatus per USP/Ph. Eur. guidelines. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determines hydrogen ion activity in a 1% w/v aqueous suspension using calibrated pH electrode and buffer standards. |
| Organic Volatile Impurities | Gas Chromatography (GC-FID) | Identifies and quantifies residual solvents (e.g., methanol, acetone, DMF) using capillary column and flame ionization detection. |
| Iron Content | Atomic Absorption Spectroscopy (AAS) | Quantifies iron after sample digestion by measuring absorption of characteristic wavelength light (248.3 nm) in acetylene-air flame. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles against standard white background under controlled lighting per ICH Q5A. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 274-278°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.