China Factory Direct
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| CAS number | 500-22-1 |
| Product name | 3-Pyridinecarboxaldehyde |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of antibiotics (e.g., pyridomycin) | Organic synthetic condensation reaction |
| Pharmaceuticals | Active pharmaceutical ingredient (API) synthesis for anticancer drugs | Construction of heterocyclic compounds |
| Agrochemicals | Intermediate in the synthesis of plant growth regulators | Oxidation or substitution reaction |
| Chemicals | Intermediate for fragrances and flavorings | Catalytic hydrogenation or reductive amination |
| Chemistry | General-purpose reagent for organic synthesis | Laboratory-scale synthesis and preparation |
| Test Item | Common Testing Method | Method Overview |
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| Purity and Assay | High-Performance Liquid Chromatography (HPLC) | Using a C18 reversed-phase column with methanol-water or acetonitrile-water as the mobile phase, detection by UV detector (λ ≈ 254 nm). Quantification is performed via external or internal standard method, enabling accurate determination of 3-pyridinecarboxaldehyde content and major impurities. |
| Impurity Analysis | Gas Chromatography-Mass Spectrometry (GC-MS) | Suitable for qualitative and quantitative analysis of volatile impurities (e.g., unreacted 3-picolyl alcohol, oxidation products). Unknown impurities are identified through comparison with mass spectral libraries. Offers high sensitivity and is ideal for trace-level impurity detection. |
| Moisture Content | Karl Fischer Titration | Determines trace moisture in samples using coulometric or volumetric methods. Applicable to moisture-sensitive 3-pyridinecarboxaldehyde raw materials and final products. Complies with pharmacopoeial standards (e.g., USP/EP), with accuracy down to ppm levels. |
| Melting Point | Melting Point Apparatus | Determines the melting range using a digital melting point apparatus (literature value: ~35–38°C). Used for preliminary purity assessment; a narrow melting range indicates high purity, while deviation suggests impurity presence. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measures maximum absorption wavelength (λ_max ≈ 270–280 nm) in ethanol or methanol. Used for qualitative confirmation and rough quantification, commonly serving as an auxiliary identification tool. |
| Inorganic Impurities (e.g., chlorides, sulfates) | General Methods from Chinese Pharmacopoeia (e.g., chloride test) | Treat sample solution according to pharmacopoeial procedures, adding reagents such as silver nitrate or barium chloride, then observe for turbidity formation. Used to control residual inorganic ion impurities in raw materials. |
| Residual Solvents | Gas Chromatography with Flame Ionization Detection (GC-FID) | According to ICH Q3C guidelines, residual solvents (e.g., ethanol, acetone, dichloromethane) are determined using headspace or direct injection GC-FID to ensure compliance with pharmaceutical-grade material requirements. |
| Water Solubility and Appearance | Visual Inspection and Solubility Test | Observe physical appearance (colorless to pale yellow liquid or low-melting solid) and test solubility in water, ethanol, and diethyl ether. Serves as a preliminary physical property control parameter. |
| Acidity/Alkalinity (pH) | pH Meter Method | Dissolve sample in water or buffer solution and measure pH using a calibrated pH meter. Monitors acidity (due to slight acidity of aldehyde group) to ensure batch-to-batch consistency. |
| Test Item | Specification |
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| Appearance | Colorless to yellow clear liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
| Refractive Index (n20/D) | 1.545–1.555 |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.