3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 500011-86-9 |
| Product name | 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 500011-86-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 500011-86-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 500011-86-9
| Industry | Application | Process |
|---|---|---|
| Pesticides | Insecticide intermediate | Used as a key intermediate in the synthesis of novel insecticides to construct biologically active pyrazole compounds |
| Pharmaceuticals | Drug development intermediate | Applied in the synthesis of heterocyclic compounds with potential pharmacological activity, enabling structural modification of anti-inflammatory and anticancer agents |
| Fine chemicals | Organic synthesis reagent | Employed as a functionalized building block in laboratory-scale cross-coupling reactions, including Suzuki and Heck couplings |
Manufacturing Quality Control of 500011-86-9
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe solid color, crystal form, and presence of impurity spots; determine melting point range (typically around 200–220°C), in compliance with pharmacopoeia or enterprise standards. |
| Assay (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use C18 column with water-acetonitrile gradient elution and UV detection at 230–260 nm. Quantify using external standard method by calculating percentage of main peak area. Typically requires ≥98.0% purity. |
| Impurity Profile (Related Substances) | HPLC (Gradient Elution) | Same system as assay, with extended run time to detect potential starting materials, intermediates, and degradation products (e.g., de-brominated, de-chlorinated, hydrolyzed products). Report impurity levels as percentage of main peak area (e.g., ≤0.5% for individual impurity, ≤1.0% for total impurities). |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection with DB-624 or HP-INNOWAX column and FID detector. Detect common organic solvents such as ethanol, acetone, DMF, acetonitrile according to ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric method. Must meet pharmacopoeial specifications (typically ≤0.5% w/w) to ensure product stability. |
| Melting Point | Capillary Melting Point Apparatus | Determine melting temperature range and compare with literature or reference standard to assess crystal form consistency. Abnormal melting points may indicate impurities or solvent residues. |
| Chlorine and Bromine Content | Ion Chromatography (IC) or Elemental Analysis (EA) | Determine chloride and bromide ion content via combustion-ion chromatography, or use elemental analyzer (CHN/Br/Cl) to verify elemental composition and molecular formula accuracy (C₁₀H₅BrClN₃O₂). |
| pH Value (Aqueous Solution) | pH Meter Measurement | Prepare a saturated aqueous solution or a defined concentration (e.g., 1 mg/mL) and measure pH to evaluate acidity (expected pH 3–5), reflecting the dissociation state of carboxylic acid group. |
| Particle Size Distribution (if in powder form) | Laser Diffraction | Applicable when active pharmaceutical ingredient is used in formulation; measure parameters such as D50 and D90 to ensure proper flowability and compressibility. |
| Heavy Metal Residues | ICP-MS or ICP-OES | After sample digestion, measure levels of heavy metals such as lead, cadmium, mercury, arsenic, and copper, complying with ICH Q3D or pharmacopoeial limits (e.g., Pb ≤ 5 ppm). |
| Crystal Form Identification | X-Ray Powder Diffraction (XRPD) | Compare characteristic diffraction patterns to confirm consistency of crystal form and avoid polymorphic variations affecting solubility and stability. |
| UV-Visible Absorption Spectroscopy (UV-Vis) | UV-Vis Spectrophotometer | Dissolve sample in acetonitrile or methanol and scan from 200–400 nm. Record characteristic absorption peaks (e.g., λmax ≈ 245 nm) for qualitative confirmation and concentration estimation. |
Technical Specifications of 500011-86-9
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 178–182°C |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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| Lot/Batch Number | *Required fields | |
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Industrial 500011-86-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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