China Factory Direct
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| CAS number | 5006-66-6 |
| Product name | 2-Hydroxy-5-pyridinecarboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a pharmaceutical intermediate in the synthesis of antitubercular agents (e.g., pyrazinamide analogues) and other nitrogen-containing heterocyclic drugs | Introduced into target molecular structures via organic synthesis reactions such as nucleophilic substitution, esterification, or amidation |
| Agrochemicals | Used as an agrochemical intermediate in the synthesis of biologically active nicotinic acid derivative insecticides or herbicides | Active molecular scaffolds are constructed through halogenation, condensation, or metal-catalyzed coupling steps |
| Chemical Research | Used as a ligand or building block in the synthesis of metal–organic frameworks (MOFs) or functional materials | Carboxyl and hydroxyl groups coordinate with metal ions to form complexes or polymers |
| Analytical Chemistry | Used as a reference standard or derivatization reagent in chromatographic analysis | Pre-column derivatization is performed to enhance detection sensitivity or selectivity |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~260 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-UV | Separation and quantification of structurally related impurities (e.g., 6-chloronicotinic acid, nicotinic acid, des-hydroxy byproducts) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify residual solvents (e.g., methanol, ethyl acetate, toluene) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS or AAS | Quantification of toxic elements (Pb, Cd, As, Hg, Ni) after acid digestion; ICP-MS offers multi-element trace-level detection, while AAS provides single-element analysis. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine total water content based on stoichiometric reaction with water. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | Incineration at 700–800 °C followed by weighing of inorganic residue, indicating inorganic impurities and catalyst residues. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, used to assess crystallinity and identity/purity (literature MP: 215–218 °C). |
| pH (1% aqueous solution) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous suspension/solution to verify acidic character consistent with carboxylic acid functionality. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample to determine D10, D50, D90 values, critical for downstream processing (e.g., filtration, blending). |
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178-182°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.