Diatrizoic Acid Dihydrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 50978-11-5 |
| Product name | Diatrizoic Acid Dihydrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Diatrizoic Acid Dihydrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Diatrizoic Acid Dihydrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Diatrizoic Acid Dihydrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Contrast agents (X-ray imaging) | Used as a raw material in the synthesis of sodium diatrizoate or diatrizoate meglumine for vascular and urinary system imaging |
| Pharmaceuticals | Diagnostics reagents | Administered intravenously or orally to enhance image contrast under X-ray |
| Research | Reference standards | Applied in analytical method development, quality control, and pharmacological studies |
Manufacturing Quality Control of Diatrizoic Acid Dihydrate
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance and Color | Visual Inspection | Observe the color and physical state of the sample under natural light or white light. It should appear as a white or off-white crystalline powder with no visible foreign matter. |
| High-Performance Liquid Chromatography (HPLC) | Compare the retention time of the sample with that of the reference standard under identical chromatographic conditions to qualitatively identify the main component. | |
| Determination of Content | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with a mobile phase of water-methanol or buffer-organic solvent, detect using a UV detector at 254 nm, and calculate the content by external standard method. The result should meet the pharmacopoeia requirements (e.g., ≥98.0%). |
| Ultraviolet-Visible Spectrophotometry (UV-Vis) | Determine absorbance at a specific wavelength (e.g., 254 nm) and calculate concentration using a standard curve method. This method is suitable for rapid preliminary quantification but has lower specificity than HPLC. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution to detect degradation products (e.g., deiodinated products, dimers), and control total impurity levels (e.g., ≤1.0%) using external standard or area normalization methods. |
| Determination of Iodine Content | Oxygen Flask Combustion Method + Ion-Selective Electrode/Titration | The sample is combusted in an oxygen flask to convert iodine into iodide ions, which are then quantified using ion-selective electrode or silver nitrate titration. This ensures compliance with pharmacopoeia requirements for iodine content (e.g., 39.0%~41.0%). |
| Clearness and Color of Solution | Turbidimetry / Colorimetry | Prepare a solution of specified concentration and compare it with a turbidity or standard color comparison solution to ensure clarity and color (e.g., clear or slightly yellow), meeting pharmacopoeia requirements. |
| Determination of Moisture | Karl Fischer Titration | Determine trace moisture content in the sample using electrochemical titration. Control moisture content (e.g., ≤0.5%) to prevent hydrolysis and affect stability. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents (e.g., ethanol, acetone, dichloromethane) from the production process using headspace injection, complying with ICH Q3C standards. |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or ICP-MS | Dissolve the sample and determine the content of heavy metals such as lead, arsenic, mercury, and cadmium, ensuring they are below pharmacopoeia limits (e.g., ≤10 ppm). |
| pH Value | pH Meter Measurement | Prepare a solution of specified concentration in water and measure pH using a calibrated pH meter, controlling it within an appropriate range (e.g., pH 5.0~7.5) to ensure formulation stability. |
| Particle Size Distribution (if applicable) | Laser Diffraction / Microscopy | For injectable powders, determine the particle size distribution to ensure solubility and injection safety (e.g., D90 < 50 μm). |
Technical Specifications of Diatrizoic Acid Dihydrate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 238°C - 242°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15.0° to -18.0° (c=1, in 1M NaOH) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Diatrizoic Acid Dihydrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of Diatrizoic Acid Dihydrate
Industrial Diatrizoic Acid Dihydrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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