China Factory Direct
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| CAS number | 50978-45-5 |
| Product name | N-ForMylsaccharin |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral intermediate for synthesizing the antidiabetic drug sitagliptin | (S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid derivative is prepared via asymmetric hydrogenation or enzymatic reduction of N-formyl saccharin, followed by multi-step coupling to construct the β-aminoamide structure |
| Pesticide R&D | Structural modification unit for novel insecticides and fungicides, enhancing lipophilicity and target binding affinity | N-Formyl saccharin moiety is incorporated to optimize electron distribution and stereochemistry of active molecules, commonly applied in late-stage functional group transformations (e.g., hydrolysis, substitution) |
| Organic Synthesis | Used as a chiral auxiliary or protecting group carrier to control reaction selectivity | Deprotonated with metal reagents (e.g., LDA) at low temperature to generate enolates, which participate in stereoselective alkylation or carbonyl addition reactions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 230 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of impurities (e.g., sugarin, formic acid derivatives) via gradient HPLC-UV, with identification and quantification relative to main peak. |
| Loss on Drying | Gravimetric (105 C drying) | Mass loss measured after drying sample at 105 C to constant weight, indicating volatile content including residual solvents and moisture. |
| Residual Solvents (e.g., DMF, THF) | GC-FID | Headspace GC with flame ionization detection for quantitative determination of common organic solvents based on retention time and calibration curves. |
| Heavy Metals (as Pb) | AAS (Flame or Graphite Furnace) | Atomic absorption spectroscopy after acid digestion; measures total heavy metal content expressed as lead equivalent. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with conductivity detection. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate ions using anion-exchange column with conductivity detection. |
| pH of Aqueous Suspension | Potentiometric Titration | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicative of purity and identity. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light by chiral components in solution; used to confirm stereochemical integrity (if applicable). |
| Residue on Ignition | Gravimetric (Sulfated Ash) | Mass of non-volatile residue remaining after high-temperature ignition (700–800 C) following sulfuric acid treatment. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration with KF reagent to quantify trace water based on stoichiometric iodine reaction. |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.